Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Molecules. 2022 May 4;27(9):2937. doi: 10.3390/molecules27092937.
Gambogic acid (GA) is a natural product with a wide range of pharmacological properties. It plays an important role in inhibiting tumor growth. A large number of GA derivatives have been designed and prepared to improve its shortcomings, such as poor water solubility, low bioavailability, poor stability, and adverse drug effects. So far, GA has been utilized to develop a variety of active derivatives with improved water solubility and bioavailability through structural modification. This article summarized the progress in pharmaceutical chemistry of GA derivatives to provide a reference and basis for further study on structural modifications of GA and expansion of its clinical applications.
藤黄酸（GA）是一种具有广泛药理活性的天然产物。它在抑制肿瘤生长方面发挥着重要作用。为了改善 GA 的缺点，如较差的水溶性、低生物利用度、较差的稳定性和不良的药物效应，已经设计和制备了大量的 GA 衍生物。到目前为止，已经通过结构修饰将 GA 用于开发各种具有改善的水溶性和生物利用度的活性衍生物。本文总结了 GA 衍生物的药物化学进展，为进一步研究 GA 的结构修饰和扩大其临床应用提供了参考和依据。
