Department of Internal and Integrative Medicine, Sozialstiftung Bamberg, Bamberg, Germany.
Department of Integrative Medicine, Medical Faculty, University of Duisburg-Essen, Bamberg, Germany.
PLoS One. 2024 Nov 13;19(11):e0313127. doi: 10.1371/journal.pone.0313127. eCollection 2024.
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) that is prevalent worldwide and associated with reduced quality of life for patients. Multimodal therapy approaches, which emphasize lifestyle modifications such as mindfulness and stress reduction, can be promising in enhancing health-related quality of life for IBD patients. However, research on multimodal therapy approaches for CD remains insufficient.
This qualitative interview study is part of a mixed-methods approach that is embedded in a randomized controlled trial. It investigates the impact of a comprehensive 10-week day clinic lifestyle modification program on the health condition and quality of life of CD patients. Telephone interviews (n = 19) were conducted three months after the program to examine individuals' viewpoints on the intervention, including perceived changes and transfer of elements into daily life. Reflexive thematic analysis was performed using MAXQDA software.
The results indicate that CD can have very individual and comprehensive impacts (psychological, physical, social), leading to reduced perceived quality of life and well-being. By participating in the program, patients wanted to find self-help options to complement conventional pharmacotherapy and actively manage their disease. Patients expressed high satisfaction with the program, feeling it provided valuable support for daily disease management. They were able to integrate adequate therapy elements into their routines to complement their care. Patients recognized significant improvements in various domains, mainly in the psychological domain, e.g., improved self-efficacy, symptom management, and, also partly physical/symptomatic and social improvements.
A multimodal stress reduction and lifestyle modification day clinic appears to be beneficial as a complementary therapy for CD patients. It offers additional options and helps patients to address individual symptoms and needs, improve their understanding of the disease and their quality of life. Although promising, further research is needed to assess its long-term effects.
ClinicalTrials.gov, identifier: NCT05182645.
克罗恩病（CD）是一种炎症性肠病（IBD），在全球范围内普遍存在，并导致患者的生活质量下降。强调生活方式改变（如正念和减轻压力）的多模式治疗方法，对于提高 IBD 患者的健康相关生活质量可能具有广阔的前景。然而，关于 CD 的多模式治疗方法的研究仍然不足。
这是一项定性访谈研究，是一项混合方法研究的一部分，该研究嵌入在一项随机对照试验中。该研究调查了为期 10 周的综合日间诊所生活方式改变方案对 CD 患者健康状况和生活质量的影响。在方案结束三个月后进行电话访谈（n=19），以检查个体对干预措施的观点，包括感知到的变化和将元素转移到日常生活中。使用 MAXQDA 软件进行反思性主题分析。
结果表明，CD 可能会产生非常个体化和全面的影响（心理、身体、社会），导致生活质量和幸福感下降。通过参与该方案，患者希望找到自我帮助的选择来补充传统的药物治疗，并积极管理他们的疾病。患者对该方案非常满意，认为该方案为日常疾病管理提供了有价值的支持。他们能够将充足的治疗元素融入日常生活中，以补充他们的护理。患者在多个领域（主要是心理领域）都认识到了显著的改善，例如，自我效能感提高、症状管理改善，以及部分身体/症状和社会改善。
多模式减压和生活方式改变日间诊所作为 CD 患者的补充治疗似乎是有益的。它提供了额外的选择，并帮助患者解决个体症状和需求，提高他们对疾病的认识和生活质量。尽管前景广阔，但仍需要进一步研究来评估其长期效果。
ClinicalTrials.gov，标识符：NCT05182645。
