Zhang Jingyuan, Lin Feng, Xu Yue, Sun Jiaxin, Zhang Lei, Chen Wenli
Department of Cerebrovascular Disease, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, China.
Department of Pharmacy, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, China.
Mol Neurobiol. 2025 May;62(5):5359-5376. doi: 10.1007/s12035-024-04624-4. Epub 2024 Nov 14.
Ischemic stroke is caused by interrupted cerebral blood flow and is a leading cause of mortality and disability worldwide. Significant advancements have been achieved in comprehending the pathophysiology of stroke and the fundamental mechanisms responsible for ischemic damage. Lactylation, as a newly discovered post-translational modification, has been reported to participate in several physiological and pathological processes. However, research on lactylation and ischemic stroke is scarce. This review summarized the current function of protein lactylation in other diseases or normal physiological processes and explored their potential link with the pathophysiological process and the reparative mechanism of ischemic stroke. We proposed that neuroinflammation, regulation of metabolism, regulation of messenger RNA translation, angiogenesis, and neurogenesis might be the bridge linking lactylation and ischemic stroke. Our study provided a novel perspective for comprehending the role of protein lactylation in the pathophysiological processes underlying ischemic stroke. Lactylation might be a promising target in drug development of ischemic stroke.
缺血性中风是由脑血流中断引起的，是全球范围内导致死亡和残疾的主要原因。在理解中风的病理生理学以及缺血性损伤的基本机制方面已经取得了重大进展。乳酸化作为一种新发现的翻译后修饰，据报道参与了多种生理和病理过程。然而，关于乳酸化与缺血性中风的研究却很少。本综述总结了蛋白质乳酸化在其他疾病或正常生理过程中的当前功能，并探讨了它们与缺血性中风病理生理过程及修复机制的潜在联系。我们提出神经炎症、代谢调节、信使核糖核酸翻译调节、血管生成和神经发生可能是连接乳酸化与缺血性中风的桥梁。我们的研究为理解蛋白质乳酸化在缺血性中风病理生理过程中的作用提供了新的视角。乳酸化可能是缺血性中风药物开发中有前景的靶点。
