Kasten G W, Martin S T
Anesth Analg. 1986 Apr;65(4):341-4.
The hemodynamic effects and ability to resuscitate animals experiencing bupivacaine cardiovascular toxicity after partial inferior vena cava occlusion were investigated in anesthetized dogs (n = 12). Partial occlusion of the inferior vena cava resulted in a 12% decrease in mean arterial pressure, a 62% decrease in cardiac output, a 66% decrease in stroke volume, and a 135% increase in systemic vascular resistance. Bupivacaine, 20 mg/kg intravenously, resulted in cardiovascular collapse in all animals. The resuscitation time for animals without partial caval occlusion was 2.1 +/- 0.5 min, whereas that for animals with partial caval occlusion was 22.2 +/- 6.9 min (P less than 0.05). Significantly increased amounts of epinephrine and NaHCO3 were required to resuscitate the animals with caval occlusion. We conclude that partial inferior vena cava occlusion can significantly alter the ability to resuscitate animals experiencing bupivacaine cardiovascular toxicity.
在麻醉犬（n = 12）中，研究了下腔静脉部分闭塞后，对经历布比卡因心血管毒性的动物进行复苏的血流动力学效应及能力。下腔静脉部分闭塞导致平均动脉压降低12%，心输出量降低62%，每搏量降低66%，全身血管阻力增加135%。静脉注射20mg/kg布比卡因可导致所有动物发生心血管衰竭。未行下腔静脉部分闭塞的动物复苏时间为2.1±0.5分钟，而行下腔静脉部分闭塞的动物复苏时间为22.2±6.9分钟（P<0.05）。复苏下腔静脉闭塞动物需要显著增加肾上腺素和碳酸氢钠的用量。我们得出结论，下腔静脉部分闭塞可显著改变对经历布比卡因心血管毒性动物的复苏能力。
