Freeman R H, Villarreal D, Vari R C, Verburg K M
Department of Physiology, University of Missouri School of Medicine, Columbia 65212.
Circ Res. 1987 Oct;61(4 Pt 2):I96-9.
Chronic constriction of the thoracic inferior vena cava results in decreased filling pressure and cardiac output, in augmented secretion rates of renin and aldosterone, and in marked sodium retention with ascites and edema formation. The goal of the present study was to determine temporal changes in the plasma concentration of immunoreactive atrial natriuretic factor (iANF) in response to chronic constriction of the thoracic inferior vena cava in the conscious dog. Following constriction of the thoracic inferior vena cava, all dogs retained sodium avidly for at least 10 days, and both plasma renin activity and plasma aldosterone concentration increased markedly (p less than 0.05). Additionally, the baseline plasma iANF of 70 +/- 5 pg/ml decreased significantly to 24 +/- 7, 26 +/- 10, and 34 +/- 11 pg/ml (p less than 0.05) on days 2, 6, and 10 following thoracic inferior vena cava constriction. Thus, chronic sodium retention in this model is associated with prolonged endocrine adjustments in the circulating levels of renin-aldosterone and iANF. We suggest that chronic decreases in the secretion of atrial natriuretic factor might contribute to the inability of the dog with constriction of the thoracic inferior vena cava to excrete sodium normally.
慢性缩窄胸段下腔静脉会导致充盈压和心输出量降低，肾素和醛固酮分泌率增加，并伴有明显的钠潴留以及腹水和水肿形成。本研究的目的是确定清醒犬在胸段下腔静脉慢性缩窄后，血浆中免疫反应性心房钠尿肽（iANF）浓度的时间变化。胸段下腔静脉缩窄后，所有犬均强烈潴留钠至少10天，血浆肾素活性和血浆醛固酮浓度均显著升高（p<0.05）。此外，胸段下腔静脉缩窄后第2、6和10天，血浆iANF的基线水平从70±5 pg/ml显著降至24±7、26±10和34±11 pg/ml（p<0.05）。因此，该模型中的慢性钠潴留与肾素 - 醛固酮和iANF循环水平的长期内分泌调节有关。我们认为，心房钠尿肽分泌的慢性减少可能导致胸段下腔静脉缩窄的犬无法正常排泄钠。
