Lundy P M, Lockwood P A, Thompson G, Frew R
Anesthesiology. 1986 Mar;64(3):359-63. doi: 10.1097/00000542-198603000-00010.
Contractile responses of isolated rabbit aortic strips to epinephrine and norepinephrine were potentiated in a dose-related manner by (+) ketamine but not by (-) ketamine (1.1 X 10(-5) M - 3.7 X 10(-4) M). Potentiation was blocked completely by pretreatment with the extraneuronal uptake inhibitor cortisol (83-138 microM) but was unaffected by the neuronal uptake inhibitor cocaine (29 microM). Responses of the rat anococcygeus muscle to these catecholamines were potentiated by both isomers, with (+) ketamine being more potent than its optical antipode. These effects were blocked completely in tissues from 6-hydroxydopamine sympathectomized animals. Results suggest that inhibition of extraneuronal uptake of catecholamines by racemic ketamine is due solely to an action of the (+) isomer, whereas both isomers appear capable of inhibiting neuronal uptake.
（+）氯胺酮能以剂量相关的方式增强离体兔主动脉条对肾上腺素和去甲肾上腺素的收缩反应，而（-）氯胺酮则不能（1.1×10⁻⁵ M - 3.7×10⁻⁴ M）。用非神经元摄取抑制剂皮质醇（83 - 138微摩尔）预处理可完全阻断这种增强作用，但神经元摄取抑制剂可卡因（29微摩尔）对其无影响。大鼠肛尾肌对这些儿茶酚胺的反应在两种异构体作用下均增强，（+）氯胺酮比其旋光对映体更有效。这些效应在6 - 羟基多巴胺交感神经切除动物的组织中被完全阻断。结果表明，外消旋氯胺酮对儿茶酚胺非神经元摄取的抑制作用仅归因于（+）异构体的作用，而两种异构体似乎都能够抑制神经元摄取。
