Cell Screening Laboratory, School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland.
Cell Screening Laboratory, School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland.
Cell Genom. 2024 Nov 13;4(11):100695. doi: 10.1016/j.xgen.2024.100695.
Establishing the subcellular distribution of all proteins encoded by the human genome remains a key objective of life science research. This is particularly important in the context of proteins that, through genetic sequencing of patients, have been identified as containing missense mutations. A recent publication in Cell highlights the prominence of protein mislocalization as a hallmark of dysfunctional proteins. The use of high-content subcellular phenotypic screens and allied technology by Lacoste and colleagues has enormous potential to change the landscape of how we approach both diagnostic and therapeutic decisions.
确定人类基因组编码的所有蛋白质的亚细胞分布仍然是生命科学研究的一个关键目标。这在蛋白质方面尤为重要，通过对患者进行基因测序，已经发现这些蛋白质含有错义突变。最近在《细胞》杂志上的一篇文章强调了蛋白质定位错误作为功能失调蛋白质的标志的突出地位。Lacoste 及其同事使用高内涵亚细胞表型筛选和相关技术具有巨大的潜力，可以改变我们处理诊断和治疗决策的方式。
