Blanchard J L, Gallina A M, Wescott R B
Am J Vet Res. 1986 Feb;47(2):309-14.
Two experiments were done to examine the severity and type of abomasal lesions induced by moderate infections of Ostertagia circumcincta in young lambs and to examine the differences in pathologic changes in lambs with monospecific and combined infections of O circumcincta and Haemonchus contortus. Observations included descriptions of gross and microscopic changes in the abomasums, as well as quantitative analysis of the thickness of the mucosa, numbers of mucus-containing cells, and inflammatory cell accumulations. Seemingly, the changes in the abomasal mucosa of lambs inoculated with O circumcincta were mild and included dilated glands, focal accumulations of lymphocytes, and significant (P less than 0.05) numerical increases of mucus-containing cells, eosinophils, and globule leukocytes, and increase of mucosal thickness when compared with those in noninoculated controls. These differences were less pronounced in lambs given anthelmintic treatment to remove O circumcincta. When H contortus infections were superimposed upon O circumcincta infection, the changes were essentially the same as those described for O circumcincta plus a small, but significant (P less than 0.05), numerical increase of globule leukocytes. Abomasal mucosa of lambs inoculated only with H contortus was more roughened and hyperemic than that of lambs with combined infections, but contained few dilated glands and globule leukocytes. Our conclusions were that moderate infection with O circumcincta did not cause severe or permanent damage to the abomasal mucosa and that such infection decreased the severity of the gross lesions produced by H contortus.
进行了两项实验，以检查幼年羔羊中度感染环形奥斯特他线虫所引起的皱胃病变的严重程度和类型，并检查环形奥斯特他线虫与捻转血矛线虫单种感染及混合感染的羔羊在病理变化上的差异。观察内容包括对皱胃大体和微观变化的描述，以及对黏膜厚度、含黏液细胞数量和炎性细胞聚集的定量分析。似乎，接种环形奥斯特他线虫的羔羊皱胃黏膜变化轻微，包括腺体扩张、淋巴细胞灶性聚集，以及与未接种对照相比，含黏液细胞、嗜酸性粒细胞和球形白细胞数量显著增加（P小于0.05），黏膜厚度增加。在接受驱虫治疗以清除环形奥斯特他线虫的羔羊中，这些差异不太明显。当捻转血矛线虫感染叠加在环形奥斯特他线虫感染之上时，变化与单独感染环形奥斯特他线虫时基本相同，只是球形白细胞数量有少量但显著的增加（P小于0.05）。仅接种捻转血矛线虫的羔羊皱胃黏膜比混合感染的羔羊更粗糙、充血，但扩张的腺体和球形白细胞较少。我们的结论是，中度感染环形奥斯特他线虫不会对皱胃黏膜造成严重或永久性损伤，且这种感染会降低捻转血矛线虫所致大体病变的严重程度。
