Dakkak A, Daoudi A, Ruckebusch Y
Am J Vet Res. 1985 Jan;46(1):209-11.
Effects of fenbendazole (7.5 mg/kg of body weight infused during 90 minutes) on abomasal transmural potential difference (PD), pH, and ionic concentrations were determined in 8 lambs fitted with permanent abomasal cannulae. Four sheep were treated before inoculation and on day 28 after inoculation, with 200,000 3rd-stage Ostertagia circumcincta larvae and 4 others were similarly inoculated with 15,000 3rd-stage Haemonchus contortus larvae. In worm-free lambs, the unique effect was an increase in Na+ concentration of the abomasal contents. The O circumcincta or H contortus-inoculated lambs had an increase in PD, pH, and Na+ concentrations. Treatment further increased these concentrations, but the effects on PD occurred and ceased earlier in sheep inoculated with O circumcincta than in those inoculated with H contortus. The results indicated that part of the changes were linked to substances produced by the parasites or by the host. The increase in PD and pH was associated with a decrease in K+ concentration and indicated that these substances stimulated HCO3- transfer.
在8只安装了永久性皱胃套管的羔羊中，测定了芬苯达唑（90分钟内输注7.5毫克/千克体重）对皱胃跨壁电位差（PD）、pH值和离子浓度的影响。4只绵羊在接种前和接种后第28天，接种200,000条第三期环纹奥斯特线虫幼虫，另外4只绵羊同样接种15,000条第三期捻转血矛线虫幼虫。在未感染蠕虫的羔羊中，唯一的影响是皱胃内容物中Na+浓度增加。接种环纹奥斯特线虫或捻转血矛线虫的羔羊，其PD、pH值和Na+浓度均升高。治疗进一步增加了这些浓度，但接种环纹奥斯特线虫的绵羊中，对PD的影响出现和消失的时间比接种捻转血矛线虫的绵羊更早。结果表明，部分变化与寄生虫或宿主产生的物质有关。PD和pH值的升高与K+浓度的降低有关，表明这些物质刺激了HCO3-转运。
