Jiang Xiaoqing, Peng Zhenyu, He Baimei, Li Siqi, Huang Qiong
Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Sci Total Environ. 2024 Dec 20;957:177534. doi: 10.1016/j.scitotenv.2024.177534. Epub 2024 Nov 15.
Chronic obstructive pulmonary disease (COPD) is a common chronic lung disease that impacts hundreds of millions of individuals worldwide. It is principally characterized by irreversible and progressive airflow limitation. Environmental pollutants, including cigarette smoke, air pollution, occupational pollutants, remain predominant risk factors for COPD and play remarkable roles in COPD progression. Despite the availability of treatments to alleviate symptoms of COPD, it continues to exert a serious health and socioeconomic burden. Ferroptosis, a unique form of iron-dependent cell death distinguished by lipid peroxidation, is implicated in various diseases. Recent studies, utilizing COPD patients samples, animal models, and Gene Expression Omnibus (GEO) database, have revealed that ferroptosis is involved in pathogenesis of COPD. Inhibiting ferroptosis signaling pathways halts the progression of COPD. This review consolidates current insights into the mechanisms of ferroptosis in environmental pollutants-induced COPD, which might offer a novel therapeutic strategy for COPD.
慢性阻塞性肺疾病（COPD）是一种常见的慢性肺部疾病，影响着全球数亿人。其主要特征是不可逆的气流受限且呈进行性发展。环境污染物，包括香烟烟雾、空气污染、职业污染物，仍然是COPD的主要危险因素，并在COPD的进展中发挥着显著作用。尽管有治疗方法可缓解COPD症状，但它仍继续造成严重的健康和社会经济负担。铁死亡是一种独特的铁依赖性细胞死亡形式，其特征为脂质过氧化，与多种疾病有关。最近利用COPD患者样本、动物模型和基因表达综合数据库（GEO）进行的研究表明，铁死亡参与了COPD的发病机制。抑制铁死亡信号通路可阻止COPD的进展。本综述总结了目前对环境污染物诱导的COPD中铁死亡机制的见解，这可能为COPD提供一种新的治疗策略。
