Taliercio C P, Vlietstra R E, Fisher L D, Burnett J C
Ann Intern Med. 1986 Apr;104(4):501-4. doi: 10.7326/0003-4819-104-4-501.
In 139 patients with preexisting abnormal renal function (serum creatinine level of 2.0 mg/dL or greater) undergoing cardiac angiography (141 examinations), the incidence of contrast nephropathy, defined as a 1 mg/dL or greater rise in serum creatinine, was 23% (95% confidence interval, 17% to 30%). Stepwise logistic regression analysis showed that contrast nephropathy was independently associated with class IV heart failure with low cardiac output (71% incidence in this subgroup; p less than 0.0001), multiple radiocontrast studies within 72 hours (50%; p = 0.002), dose of radiocontrast administered (p = 0.009), and insulin-dependent diabetes mellitus (44%; p = 0.007). Age, hypertension, and hyperuricemia were not associated. In patients without low cardiac output, other radiocontrast tests, or insulin-dependent diabetes mellitus, there was a 2% incidence of contrast nephropathy in those who received less than 125 mL radiocontrast and a 19% incidence in those who received 125 mL or greater.
在139例已有肾功能异常（血清肌酐水平为2.0mg/dL或更高）且接受心脏血管造影检查（共141次检查）的患者中，造影剂肾病（定义为血清肌酐升高1mg/dL或更多）的发生率为23%（95%置信区间为17%至30%）。逐步逻辑回归分析显示，造影剂肾病与低心输出量的IV级心力衰竭（该亚组发生率为71%；p<0.0001）、72小时内多次进行放射性造影剂检查（50%；p = 0.002）、放射性造影剂给药剂量（p = 0.009）以及胰岛素依赖型糖尿病（44%；p = 0.007）独立相关。年龄、高血压和高尿酸血症与之无关。在无心输出量低、无其他放射性造影剂检查或无胰岛素依赖型糖尿病的患者中，接受放射性造影剂少于125mL的患者造影剂肾病发生率为2%，接受125mL或更多放射性造影剂的患者发生率为19%。
