Oien Michael P, Tuncer Onur, Nascene David
Mayo Clinic Department of Radiology, Mayo Building West, 2nd Floor 200 First St. SW, Rochester, MN, 55905, USA.
Medical School, Department of Radiology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.
Neuroradiology. 2025 Jan;67(1):277-285. doi: 10.1007/s00234-024-03505-w. Epub 2024 Nov 15.
Interhypothalamic adhesions (IHAs) have been reported only in the pediatric population, with unknown prevalence and histological composition. We aim to demonstrate their prevalence, assess their persistence through longitudinal imaging, classify IHAs by anatomical distribution, explore their structure, and report associated pathologies.
A retrospective review was conducted on consecutive pediatric brain MRI studies obtained between January 2012, and December 2013. The presence of an IHA was only confirmed when observed on at least two planes. For each IHA, cross-sectional area was calculated, and signal intensities were measured at the center on sagittal T2WIs. Signal intensities were also measured in both cerebral white matter and gray matter for normalization and comparison. Patient demographics and clinical information were collected from electronic charts.
Out of 1550 patients (0-17.9 years), 33 (19 males, 14 females) had an IHA, resulting in a 2.13% prevalence. Follow-up images were available for 19 IHA-positive patients, and IHAs were again seen in 92% of the follow-up scans (71/77). Normalized IHA signal highly correlated with normalized gray matter signal (r = 0.83, P < 0.001), but not with normalized white matter signal (r = -0.16, p = 0.494). Common co-occurring pathologies included hydrocephalus (n = 9), prematurity (n = 8), and corpus callosum abnormalities (n = 7). All type 3 IHAs (3/3) were accompanied by pituitary pathologies.
IHAs have a prevalence of 2.13% in our cohort, and the majority persist in longitudinal studies. They showed gray matter signal intensity and Type 3 IHAs exclusively accompanied pituitary abnormalities.
下丘脑间粘连（IHAs）仅在儿科人群中有报道，其患病率及组织学构成尚不清楚。我们旨在证明其患病率，通过纵向成像评估其持续性，按解剖分布对IHAs进行分类，探究其结构，并报告相关病理情况。
对2012年1月至2013年12月期间连续获得的儿科脑MRI研究进行回顾性分析。仅在至少两个层面观察到IHA时才予以确认。对于每个IHA，计算其横截面积，并在矢状位T2加权像上测量中心处的信号强度。还在脑白质和灰质中测量信号强度以进行标准化和比较。从电子病历中收集患者人口统计学和临床信息。
在1550例患者（0至17.9岁）中，33例（19例男性，14例女性）存在IHA，患病率为2.13%。19例IHA阳性患者有随访图像，92%的随访扫描（71/77）中再次见到IHA。标准化IHA信号与标准化灰质信号高度相关（r = 0.83，P < 0.001），但与标准化白质信号无关（r = -0.16，p = 0.494）。常见的并发疾病包括脑积水（n = 9）、早产（n = 8）和胼胝体异常（n = 7）。所有3型IHA（3/3）均伴有垂体病变。
在我们的队列中，IHA的患病率为2.13%，大多数在纵向研究中持续存在。它们显示灰质信号强度，且3型IHA仅伴有垂体异常。
