Department of Ophthalmology and Visual Sciences, University of Adelaide, North Terrace, SA, 5000, Australia.
Department of Ophthalmology, Royal Adelaide Hospital, Port Road, Adelaide, SA, 5000, Australia.
Int Ophthalmol. 2024 Nov 14;44(1):431. doi: 10.1007/s10792-024-03352-x.
This study aimed to investigate lacrimal gland (LG) enlargement in thyroid eye disease (TED) patients on magnetic resonance imaging (MRI).
A retrospective review was conducted on TED patients who had undergone fat-suppressed contrast-enhanced T1-weighted MRI of the orbits. The lacrimal gland was segmented on OsiriX in consecutive axial and coronal slices to determine its volume. Enlargement was defined as a volume greater than 1100mm, based on previous normative data. Asymmetric enlargement was defined if one side was enlarged but the contralateral side was not. Clinical data including presentation (active/inactive) and presence or absence of dysthyroid optic neuropathy was evaluated.
The study population consisted of 88 orbits from forty-four patients with a mean age of 53 ± 15 years, with 29 (65%) being female. Twelve patients (27%) had LG enlargement, with eight (18%) having bilateral enlargement and four (9%) having asymmetric enlargement. There was no significant difference in age (p = 0.17) or sex (p = 0.44) between the LG enlarged and non-enlarged groups. There was also no significant difference in the clinical activity (p = 0.46) or prevalence of dysthyroid optic neuropathy (p = 0.63) between the LG enlarged orbits and non-LG enlarged orbits.
Lacrimal gland enlargement may be observed in approximately thirty percent of TED patients, with asymmetric enlargement in approximately ten percent of cases.
本研究旨在探讨甲状腺眼病（TED）患者磁共振成像（MRI）下泪腺增大的情况。
对接受过眼眶脂肪抑制对比增强 T1 加权 MRI 的 TED 患者进行回顾性研究。在 OsiriX 上对连续的轴位和冠状位切片进行泪腺分割，以确定其体积。根据既往的正常数据，将体积大于 1100mm 定义为增大。如果一侧增大而对侧未增大，则定义为不对称增大。评估的临床数据包括表现（活动/不活动）以及是否存在甲状腺眼病性视神经病变。
研究人群由 44 例患者的 88 只眼眶组成，平均年龄为 53±15 岁，其中 29 例（65%）为女性。12 例（27%）患者存在泪腺增大，其中 8 例（18%）为双侧增大，4 例（9%）为不对称增大。泪腺增大组与非增大组在年龄（p=0.17）或性别（p=0.44）方面无显著差异。泪腺增大眼眶与非泪腺增大眼眶在临床活动（p=0.46）或甲状腺眼病性视神经病变的患病率（p=0.63）方面也无显著差异。
约 30%的 TED 患者可能出现泪腺增大，约 10%的患者为不对称增大。
