Verdeal K, Erturk E, Rose D P
Anticancer Res. 1986 Jan-Feb;6(1):5-10.
Female Sprague-Dawley strain rats were given 3 i.v. injections of N-nitrosomethylurea, 4 mg/100 g body weight, at 4 weekly intervals. All rats developed mammary tumors, which were then excised to prolong survival. Seven months after the first injection, 14 of 27 (52%) rats examined has adenomatous hyperplasia of the endometrium, and 6 (22%) had endometrial carcinomas. The remaining 7 animals had varying degrees of hyperplasia, some with squamous metaplasia. Endocrine pathology in these same rats included hyperplasia of the eosinophilic and basophilic cells of the hypophysis (100%), adrenocortical adenomas (81%), polycystic ovaries (70%), thyroid follicular enlargement with colloid accumulation (67%), and parathyroid hyperplasia (7%). Serum TSH levels were elevated in the rats with thyroid abnormalities.
对雌性斯普拉格-道利品系大鼠静脉注射3次N-亚硝基甲脲，剂量为4毫克/100克体重，每隔4周注射一次。所有大鼠均发生乳腺肿瘤，随后将肿瘤切除以延长生存期。首次注射7个月后，在检查的27只大鼠中，有14只（52%）出现子宫内膜腺瘤样增生，6只（22%）患有子宫内膜癌。其余7只动物有不同程度的增生，有些伴有鳞状化生。这些大鼠的内分泌病理学表现包括垂体嗜酸性和嗜碱性细胞增生（100%）、肾上腺皮质腺瘤（81%）、多囊卵巢（70%）、甲状腺滤泡增大伴胶体蓄积（67%）和甲状旁腺增生（7%）。甲状腺异常的大鼠血清促甲状腺激素水平升高。
