Maruhashi Tatsuya, Kajikawa Masato, Kishimoto Shinji, Yamaji Takayuki, Harada Takahiro, Mizobuchi Aya, Tanigawa Shunsuke, Yusoff Farina Mohamad, Nakano Yukiko, Chayama Kazuaki, Nakashima Ayumu, Goto Chikara, Higashi Yukihito
Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hypertens Res. 2025 Jan;48(1):6-14. doi: 10.1038/s41440-024-01972-5. Epub 2024 Nov 14.
Experimental and clinical studies have suggested atherosclerotic effects of uric acid (UA) on vascular smooth muscle cells (VSMCs). Nitroglycerine-induced vasodilation (NID), a control test for flow-mediated vasodilation, can be used as a possible marker of VSMC dysfunction. However, there is little information on the association between UA and NID. Therefore, we investigated the association between serum UA levels and NID according to sex. We measured NID of the brachial artery in 598 women (mean age: 66.2 ± 12.0 years) and 1008 men (mean age: 59.0 ± 18.0 years). In women, the mean serum UA level was 5.06 ± 1.24 mg/dL. Serum UA levels were negatively correlated with NID (p < 0.001), and NID significantly decreased with increasing serum UA levels (≤4.0 mg/dL, 13.4 ± 6.4%; 4.0 to ≤5.0 mg/dL, 11.4 ± 5.3%; 5.0 to ≤6.0 mg/dL, 10.8 ± 5.7%; >6.0 mg/dL, 9.7 ± 5.7%; p < 0.001). The prevalence of VSMC dysfunction, defined as NID < 8.4%, the division points for the lowest and middle tertiles of NID in women, increased with increasing serum UA levels ( ≤ 4.0 mg/dL, 23.3%; 4.0 to ≤5.0 mg/dL, 30.9%; 5.0 to ≤6.0 mg/dL, 36.4%; >6.0 mg/dL, 44.6%; p < 0.001). Multiple logistic regression analysis showed a significant association between serum UA levels and VSMC dysfunction (odds ratio, 1.21; 95% confidence interval, 1.02─1.43; p = 0.03). There was no interaction between age (<50 or ≥50 years) and the effect of serum UA levels on VSMC dysfunction (p interaction = 0.88). In contrast, no association was observed between serum UA levels and NID in men. Serum UA levels were significantly associated with VSMC dysfunction as assessed by NID in women.
实验和临床研究表明，尿酸（UA）对血管平滑肌细胞（VSMC）具有动脉粥样硬化作用。硝酸甘油诱导的血管舒张（NID）作为血流介导的血管舒张的对照试验，可作为VSMC功能障碍的一个可能标志物。然而，关于UA与NID之间关联的信息很少。因此，我们根据性别调查了血清UA水平与NID之间的关联。我们测量了598名女性（平均年龄：66.2±12.0岁）和1008名男性（平均年龄：59.0±18.0岁）肱动脉的NID。在女性中，血清UA平均水平为5.06±1.24mg/dL。血清UA水平与NID呈负相关（p<0.001），且随着血清UA水平升高（≤4.0mg/dL，13.4±6.4%；4.0至≤5.0mg/dL，11.4±5.3%；5.0至≤6.0mg/dL，10.8±5.7%；>6.0mg/dL，9.7±5.7%；p<0.001），NID显著降低。VSMC功能障碍的患病率定义为NID<8.4%（女性NID最低和中间三分位数的分界点），随着血清UA水平升高而增加（≤4.0mg/dL，23.3%；4.0至≤5.0mg/dL，30.9%；5.0至≤6.0mg/dL，36.4%；>6.0mg/dL，44.6%；p<0.001）。多因素logistic回归分析显示血清UA水平与VSMC功能障碍之间存在显著关联（比值比，1.21；95%置信区间，1.02─1.43；p=0.03）。年龄（<50或≥50岁）与血清UA水平对VSMC功能障碍的影响之间无交互作用（p交互作用=0.88）。相比之下，在男性中未观察到血清UA水平与NID之间的关联。血清UA水平与通过NID评估的女性VSMC功能障碍显著相关。
Zotero 插件