Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University.
Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital.
J Atheroscler Thromb. 2022 Nov 1;29(11):1588-1602. doi: 10.5551/jat.63285. Epub 2021 Dec 23.
An experimental study showed that potassium inhibits the formation of reactive oxygen species by vascular cells. The purpose of this study was to investigate the association between serum potassium levels and vascular function.
We measured flow-mediated vasodilation (FMD) as an index of endothelial function in 3045 subjects (1964 men; mean age, 62.3±13.8 years) and nitroglycerine-induced vasodilation (NID) as an index of vascular smooth muscle function in 1578 subjects (1001 men; mean age, 61.8±16.3 years).
In the 3045 subjects, there was a significant positive correlation between FMD and serum potassium levels (r=0.09, P＜0.001). Multivariate analysis revealed that serum potassium levels were significantly associated with FMD (β=0.109, P＜0.001). When subjects were divided into two groups based on treatment with drugs that could alter serum potassium levels, the association between serum potassium levels and FMD was significant both in subjects with (β=0.096, P＜0.001) and subjects without (β=0.123, P＜0.001) treatment with drugs that could alter serum potassium levels. In the 1578 subjects, there was a significant positive correlation between NID and serum potassium levels (r=0.11, P＜0.001). Multivariate analysis revealed that serum potassium levels were significantly associated with NID (β=0.098, P＜0.001). The association between serum potassium levels and NID was significant both in subjects with (β=0.121, P=0.001) and subjects without (β=0.083, P=0.03) treatment with drugs that could alter serum potassium levels.
Serum potassium levels of 4.5-＜5.0 mmol/L are associated with better vascular function regardless of the presence or absence of treatment with drugs that could alter serum potassium levels.
一项实验研究表明，钾可抑制血管细胞中活性氧物质的形成。本研究旨在探讨血清钾水平与血管功能之间的关系。
我们测量了 3045 例受试者（男 1964 例；平均年龄 62.3±13.8 岁）的血流介导的血管舒张（FMD）作为内皮功能的指标，以及 1578 例受试者（男 1001 例；平均年龄 61.8±16.3 岁）的硝酸甘油诱导的血管舒张（NID）作为血管平滑肌功能的指标。
在 3045 例受试者中，FMD 与血清钾水平呈显著正相关（r=0.09，P＜0.001）。多变量分析显示，血清钾水平与 FMD 显著相关（β=0.109，P＜0.001）。根据可能改变血清钾水平的药物治疗将受试者分为两组时，在接受（β=0.096，P＜0.001）和未接受（β=0.123，P＜0.001）可能改变血清钾水平的药物治疗的受试者中，血清钾水平与 FMD 之间的关联均具有统计学意义。在 1578 例受试者中，NID 与血清钾水平呈显著正相关（r=0.11，P＜0.001）。多变量分析显示，血清钾水平与 NID 显著相关（β=0.098，P＜0.001）。在接受（β=0.121，P=0.001）和未接受（β=0.083，P=0.03）可能改变血清钾水平的药物治疗的受试者中，血清钾水平与 NID 之间的关联均具有统计学意义。
无论是否接受可能改变血清钾水平的药物治疗，血清钾水平为 4.5-＜5.0mmol/L 与更好的血管功能相关。
