Department of Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong Province, 510623, China.
Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian Province, 350012, China.
Virol J. 2024 Nov 14;21(1):292. doi: 10.1186/s12985-024-02537-1.
Infection is the cause of diarrhoea, and rotaviruses and adenoviruses are important pathogens in children.
A retrospective study was conducted on 144,067 children with diarrhoea between 2014 and 2023 in China. We used the colloidal gold method to detect intestinal adenovirus and rotavirus A antigens in faeces. The epidemiological characteristics of these viruses and the impact of meteorological factors on them were analysed before and after coronavirus disease 2019 (COVID-19) pandemic.
During this decade, the positive rate of adenovirus infection was 6.41%, while the positive rate of rotavirus A infection was 11.81%, higher than that of adenovirus infection. The positive rate of adenovirus and rotavirus A coinfection was 1.92%. The positive rates of adenovirus, rotavirus A and coinfection showed a fluctuating trend, and suddenly decreased in 2020. There was an apparent decrease of positive rate of rotavirus A, with a decrease of 57.27%, during 2020-2023. Surprisingly, the positive rate of adenovirus infection exceeded that of rotavirus A infection in 2021 and 2023. During the COVID-19 pandemic, the proportion of female patients and children over two years of age infected with adenovirus or rotavirus A increased, while the proportion of cases in winter decreased. In addition, we found that the positive rate of rotavirus A infection was related to average temperature and sunshine, and the positive rate of adenovirus and rotavirus A coinfection was only related to sunshine. However, these correlations disappeared during the COVID-19 pandemic.
This study revealed the recent prevalence of adenovirus and rotavirus A infections in children with diarrhoea in south-central China and provided a theoretical basis for the prevention and control of viral diarrhoea.
感染是导致腹泻的原因，轮状病毒和腺病毒是儿童的重要病原体。
对 2014 年至 2023 年间中国 144067 例腹泻儿童进行了回顾性研究。我们使用胶体金法检测粪便中的肠道腺病毒和轮状病毒 A 抗原。分析了新冠疫情前后这些病毒的流行病学特征以及气象因素对它们的影响。
在这十年中，腺病毒感染的阳性率为 6.41%，而轮状病毒 A 感染的阳性率为 11.81%，高于腺病毒感染。腺病毒和轮状病毒 A 混合感染的阳性率为 1.92%。腺病毒、轮状病毒 A 和混合感染的阳性率呈波动趋势，2020 年突然下降。轮状病毒 A 的阳性率明显下降，2020-2023 年间下降了 57.27%。令人惊讶的是，2021 年和 2023 年腺病毒感染的阳性率超过了轮状病毒 A。在新冠疫情期间，感染腺病毒或轮状病毒 A 的女性患者和 2 岁以上儿童的比例增加，而冬季的病例比例减少。此外，我们发现轮状病毒 A 感染的阳性率与平均温度和日照有关，腺病毒和轮状病毒 A 混合感染的阳性率仅与日照有关。然而，这些相关性在新冠疫情期间消失了。
本研究揭示了中国中南地区儿童腹泻中腺病毒和轮状病毒 A 的近期流行情况，为病毒性腹泻的防控提供了理论依据。
