Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
BMC Infect Dis. 2024 May 9;24(1):478. doi: 10.1186/s12879-024-09386-x.
Human adenoviruses (HAdVs) have always been suggested as one of the main causes of gastroenteritis in children. However, no comprehensive report on the global epidemiology of these viruses in pediatric gastroenteritis is available.
A systematic search was conducted to obtain published papers from 2003 to 2023 in three main databases PubMed, Scopus, and Web of Science.
The estimated global pooled prevalence of HAdV infection in children with gastroenteritis was 10% (95% CI: 9-11%), with a growing trend after 2010. The highest prevalence was observed in Africa (20%, 95% CI: 14-26%). The prevalence was higher in inpatients (11%; 95% CI: 8-13%) and patients aged 5 years old and younger (9%; 95% CI: 7-10%). However, no significant difference was observed between male and female patients (P = 0.63). The most prevalent species was found to be the species F (57%; 95% CI: 41-72%). The most common HAdVs observed in children with gastroenteritis were types 40/41, 38, and 2. Analysis of case-control studies showed an association between HAdV and gastroenteritis in children (OR: 2.28, 95% CI; 1.51-3.44).
This study provided valuable insights into the importance of HAdVs in children with gastroenteritis, especially in hospitalized and younger children. The results can be used in future preventive measurements and the development of effective vaccines.
人类腺病毒（HAdV）一直被认为是儿童胃肠炎的主要病因之一。然而，目前尚无关于这些病毒在儿科胃肠炎中的全球流行病学的综合报告。
系统检索了 2003 年至 2023 年在 PubMed、Scopus 和 Web of Science 三个主要数据库中发表的文献。
估计全球胃肠炎儿童中 HAdV 感染的综合患病率为 10%（95%CI：9-11%），2010 年后呈上升趋势。在非洲，患病率最高（20%，95%CI：14-26%）。住院患者（11%，95%CI：8-13%）和 5 岁及以下儿童（9%，95%CI：7-10%）的患病率更高。然而，男女性别之间无显著差异（P=0.63）。最常见的病毒株是 F 种（57%，95%CI：41-72%）。胃肠炎儿童中最常见的 HAdV 是 40/41、38 和 2 型。病例对照研究分析显示 HAdV 与儿童胃肠炎之间存在关联（OR：2.28，95%CI：1.51-3.44）。
本研究深入了解了 HAdV 在儿童胃肠炎中的重要性，特别是在住院和年幼儿童中。研究结果可用于未来的预防措施和有效疫苗的开发。
