Cron David C, Kuk Arnold E, Parast Layla, Husain S Ali, Welten Vanessa M, Yu Miko, Mohan Sumit, Adler Joel T
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Surgery at Brigham and Women's, Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Clin Transplant. 2024 Nov;38(11):e70024. doi: 10.1111/ctr.70024.
How offer notifications are distributed early in the kidney allocation timeline, including how widely they are offered, is unclear. A better understanding of offer notification practices across organ procurement organizations (OPOs) may identify opportunities for more efficient allocation.
We merged the Scientific Registry of Transplant Recipients potential transplant recipient file with additional offer notification time stamps to identify 54 631 deceased-donor kidney match runs from 2017 to 2023. Offer notifications for a given match run are sent to candidates/centers in "batches." We quantified the number of offers in the initial batch-which theoretically reflects the OPO's initial estimate of how widely a kidney should be offered-and compared this metric across OPOs.
Kidneys were offered to a median of 14 candidates (IQR 9-38) in the first batch of notifications, and this varied across OPOs from 3 to 746 candidates per initial batch. Batch size at the OPO-level did not correlate with rank at kidney placement or OPO nonuse rate. OPOs in the highest quartile of batch size sent more offers (median 100) than presumably necessary to place kidneys (median rank at placement 21), and OPOs in the lowest quartile of batch size sent fewer offers (6) than needed to place kidneys (rank at placement 19).
Offer notification practices vary widely across OPOs, and many OPOs offer kidneys far more widely than necessary for placement. Optimization of offer notification practices may reduce unnecessary communications. Further research into allocation processes is needed to identify opportunities to improve efficiency of allocation for OPOs and transplant centers.
在肾脏分配时间线的早期,如何分配供体器官的通知,包括通知的范围有多广,目前还不清楚。更好地了解器官获取组织(OPO)的供体器官通知实践,可能会发现更有效地分配供体器官的机会。
我们将器官获取共享联合网络(SRTR)潜在的移植受者文件与额外的供体器官通知时间戳合并,以确定 2017 年至 2023 年期间的 54631 例死亡供体肾脏匹配运行。给定匹配运行的供体器官通知以“批次”的形式发送给候选者/中心。我们量化了初始批次中的供体器官通知数量-理论上反映了 OPO 对供体器官应广泛提供的初步估计-并比较了不同 OPO 之间的这一指标。
在第一批供体器官通知中,肾脏提供给中位数为 14 名候选者(IQR9-38),而在不同的 OPO 之间,初始批次中每批提供的候选者数量从 3 名到 746 名不等。OPO 层面的批次大小与肾脏放置的等级或 OPO 不使用率无关。在批次大小最高的四分位数的 OPO 发送的供体器官通知数量更多(中位数 100 个),超过了放置肾脏所需的数量(中位数放置等级 21),而在批次大小最低的四分位数的 OPO 发送的供体器官通知数量更少(6 个),不足以放置肾脏(放置等级 19)。
供体器官通知实践在 OPO 之间差异很大,许多 OPO 提供的供体器官远远超过了放置所需的数量。优化供体器官通知实践可能会减少不必要的沟通。需要进一步研究分配过程,以确定为 OPO 和移植中心提高分配效率的机会。