Nomura Tadashi, Satake Hiroshi, Hata Yuki, Sakakibara Shunsuke, Terashi Hiroto
Department of Plastic Surgery, Kobe University Graduate School of Medicine, Kobe, JPN.
Department of Plastic Surgery, Japan Community Healthcare Organization (JCHO) Osaka Hospital, Osaka, JPN.
Cureus. 2024 Oct 14;16(10):e71478. doi: 10.7759/cureus.71478. eCollection 2024 Oct.
Orbital lymphatic malformations significantly impair visual function, with inflammation contributing to corneal dryness and diplopia due to exophthalmos. Disease progression may lead to blindness, and in severe cases, exenteration may be required. We treated two symptomatic cases of adult orbital slow-flow vascular malformations with oral sirolimus. Although the patients maintained good visual acuity before treatment, prominent exophthalmos posed a substantial risk to visual function. After medication, eyeball proptosis improved significantly in all cases, with magnetic resonance imaging volumetry analysis showing a reduction of 28.5% to 82.1%. This treatment demonstrated minimal side effects and may serve as an initial therapeutic option.
眼眶淋巴管畸形会显著损害视觉功能，炎症会导致角膜干燥以及因眼球突出引起复视。疾病进展可能导致失明，严重时可能需要进行眼眶内容剜除术。我们用口服西罗莫司治疗了两例有症状的成人眼眶缓慢血流性血管畸形。尽管患者在治疗前视力良好，但明显的眼球突出对视觉功能构成了重大风险。用药后，所有病例的眼球突出均有显著改善，磁共振成像容积分析显示减少了28.5%至82.1%。该治疗显示出极小的副作用，可作为初始治疗选择。
