Snigerevskaia E S, Veselov V S
Arkh Anat Gistol Embriol. 1986 Jan;90(1):59-65.
As demonstrates the electron microscopic investigation of the human liver at complicated forms of cholelithiasis, there is a stage-by-stage destruction of intercellular junctions and a change in the plasmolemma structure of hepatocytes depending on the degree of the disease. The greatest disorder in the plasmolemma structure is observed at gangrenous calculous cholecystitis, as well as at mechanical jaundice and suppurative cholangitis, dependent on choledocholithiasis. The most sensitive are the gap junctions; desmosomes and intermediate junctions are the second to suffer. The structure of the tight junctions is the last to be disturbed. This results in loss of specificity by different areas of plasmolemma in the hepatocytes, and the hepatocytes themselves loose their polarity. These alterations are evidently irriversible and result in death of the cells.
正如对复杂形式胆石症患者肝脏进行的电子显微镜检查所示，根据疾病程度，细胞间连接会逐步遭到破坏，肝细胞的质膜结构也会发生变化。在坏疽性结石性胆囊炎、机械性黄疸以及由胆总管结石引起的化脓性胆管炎中，观察到质膜结构的紊乱最为严重。最敏感的是缝隙连接；桥粒和中间连接次之受损。紧密连接的结构最后受到干扰。这导致肝细胞质膜不同区域丧失特异性，肝细胞本身也失去极性。这些改变显然是不可逆的，会导致细胞死亡。
