Zufarov K A, Sadriddinov A F
Arkh Patol. 1987;49(4):55-61.
Morphogenesis of hepatocellular necrosis was studied on liver biopsy samples from patients with cholelithiasis complicated with gangrenous cholecystitis. In patients operated on 5-7 days after the onset on the disease there were foci of hepatic parenchyma necrosis infiltrated with polymorphonuclear leukocytes (PNL) with relevant introduction into the hepatocytes. In patients operated on in 10-15 days disintegration of cellular structures, removal of necrotic masses and reparation proceed with participation of PNL in line with tissue macrophages and stellate reticuloendotheliocytes, poorly differentiated and mature fibroblast-like cells. Finally, bundles of collagen fibres are forming and introduced at the sites of hepatocellular necrosis.
对患有胆结石并发坏疽性胆囊炎患者的肝脏活检样本进行肝细胞坏死的形态发生研究。在疾病发作后5 - 7天接受手术的患者中，肝实质坏死灶有中性粒细胞浸润，且中性粒细胞已侵入肝细胞。在发病后10 - 15天接受手术的患者中，细胞结构解体、坏死物质清除及修复过程在中性粒细胞以及组织巨噬细胞和星状网状内皮细胞、低分化和成熟的成纤维细胞样细胞参与下进行。最后，胶原纤维束形成并出现在肝细胞坏死部位。
