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Non-invasive algorithms could outperform HVPG in selecting candidates for non-selective beta-blockers in cirrhosis.

作者信息

Vanderschueren Emma, Laleman Wim

机构信息

Department of Gastroenterology and Hepatology, Section of Liver & Biliopancreatic Disorders and Liver Transplantation, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

Department of Gastroenterology and Hepatology, Section of Liver & Biliopancreatic Disorders and Liver Transplantation, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Department of Internal Medicine B, University of Münster, Münster Germany.

出版信息

J Hepatol. 2025 May;82(5):e263-e264. doi: 10.1016/j.jhep.2024.11.011. Epub 2024 Nov 13.

DOI:10.1016/j.jhep.2024.11.011
PMID:39547586
Abstract
摘要

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Non-invasive algorithms could outperform HVPG in selecting candidates for non-selective beta-blockers in cirrhosis.在为肝硬化患者选择非选择性β受体阻滞剂的候选者时,非侵入性算法可能比肝静脉压力梯度(HVPG)表现更优。
J Hepatol. 2025 May;82(5):e263-e264. doi: 10.1016/j.jhep.2024.11.011. Epub 2024 Nov 13.
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Exploring algorithms to select candidates for non-selective beta-blockers in cirrhosis: A post hoc analysis of the PREDESCI trial.探索用于选择肝硬化患者非选择性β受体阻滞剂候选者的算法:PREDESCI试验的事后分析
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Liver stiffness can predict decompensation and need for beta-blockers in compensated cirrhosis: a step beyond Baveno-VI criteria.肝脏硬度可以预测代偿性肝硬化的失代偿和β受体阻滞剂的需求:超越 Baveno-VI 标准的一步。
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The prognostic value of HVPG-response to non-selective beta-blockers in patients with NASH cirrhosis and varices.非选择性β受体阻滞剂治疗应答对 NASH 肝硬化合并静脉曲张患者的预后价值。
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Early primary prophylaxis with beta-blockers does not prevent the growth of small esophageal varices in cirrhosis: a randomized controlled trial.β受体阻滞剂早期一级预防不能阻止肝硬化患者小食管静脉曲张的进展:一项随机对照试验。
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Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis.代谢组学揭示了潜在的生物标志物,可预测肝硬化患者对普萘洛尔的急性 HVPG 反应。
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Non-selective β-blockers improve the correlation of liver stiffness and portal pressure in advanced cirrhosis.非选择性β受体阻滞剂可改善晚期肝硬化患者肝硬度与门脉压力的相关性。
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β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial.β 受体阻滞剂预防有临床显著门静脉高压症的肝硬化失代偿(PREDESCI):一项随机、双盲、安慰剂对照、多中心试验。
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Complications of cirrhosis. I. Portal hypertension.肝硬化的并发症。I. 门静脉高压
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Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrhosis.二维剪切波弹性成像测量的肝脏硬度在肝硬化晚期肝移植候选者中高值时可预测肝静脉压力梯度。
PLoS One. 2021 Jan 7;16(1):e0244934. doi: 10.1371/journal.pone.0244934. eCollection 2021.

引用本文的文献

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Understanding clinically significant portal hypertension: an in-depth look at pathogenesis, diagnosis and treatment.了解具有临床意义的门静脉高压症:深入探讨发病机制、诊断与治疗
Ann Gastroenterol. 2025 Jul-Aug;38(4):380-391. doi: 10.20524/aog.2025.0980. Epub 2025 Jun 25.
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Transjugular diagnostic procedures in hepatology: Indications, techniques and interpretation.肝病学中的经颈静脉诊断程序:适应证、技术与解读
JHEP Rep. 2025 Apr 29;7(8):101437. doi: 10.1016/j.jhepr.2025.101437. eCollection 2025 Aug.