白细胞介素多态性（rs4073、rs1800925、rs1179251、rs1179246、rs2227485、rs17855750和rs153109）与结直肠癌风险关联的Meta分析
A Meta-Analysis of Association Between Interleukin Polymorphisms (rs4073, rs1800925, rs1179251, rs1179246, rs2227485, rs17855750, and rs153109) and Colorectal Cancer Risk.
作者信息
Sadafi Sepehr, Amirifard Nasrin, Aleagha Omid Emami, Mirbahari Seyed Ghasem, Sadeghi Masoud
机构信息
Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Biochem Genet. 2024 Nov 15. doi: 10.1007/s10528-024-10969-1.
Interleukins (ILs) play a significant role in triggering the inflammatory response in blood vessels and immune cells. A systematic review and meta-analysis were conducted to investigate the relationship between IL-8 (rs4073), IL-13 (rs1800925), IL-22 (rs1179251, rs1179246, and rs2227485), and IL-27 (rs17855750 and rs153109) polymorphisms and the risk of developing colorectal cancer (CRC). Four databases were searched up until October 13, 2023, without any restrictions, to find relevant studies. The association was evaluated using crude odds ratios (ORs) and 95% confidence intervals in five genetic models. A total of twenty-three articles were entered into the meta-analysis. The pooled ORs (p-values) for the IL-8 (rs4073) polymorphism were 0.98 (0.63), 0.93 (0.44), 0.89 (0.13), 0.94 (0.38), and 0.99 (0.90) for studies following HWE without heterogeneity, and for all studies with high heterogeneity were 1.03 (0.69), 1.30 (0.07), 1.04 (0.71), 1.12 (0.20), and 1.23 (0.06). For the IL-13 (rs1800925) polymorphism, the pooled ORs were 1.44 (0.06), 2.58 (0.0004), 1.72 (0.16), 1.82 (0.09), and 2.37 (0.001) in AHHDR models, respectively. The pooled ORs of IL-22 (rs1179251) polymorphism for AHHDR models were 0.97 (0.92), 0.92 (0.90), 0.98 (p = 0.95), 1.08 (0.87), and 0.96 (0.82), respectively. The pooled ORs of IL-22 (rs1179246) polymorphism for AHHDR models were 0.98 (0.67), 0.97 (0.80), 0.92 (0.36), 0.93 (0.42), and 1.02 (0.84), respectively. The pooled ORs of IL-22 (rs2227485) polymorphism for AHHDR models were 1.47 (0.02), 2.03 (0.02), 1.28 (0.29), 1.52 (0.06), and 1.70 (0.04), respectively. The pooled ORs of IL-27 (rs17855750) polymorphism for AHHDR models were 0.53 (0.46), 0.19 (0.28), 1.10 (0.60), 0.55 (0.58), and 0.27 (p = 0.05), respectively. The pooled ORs of IL-27 (rs153109) polymorphism for AHHDR models were 1.28 (0.007), 1.45 (0.002), 1.40 (0.0002), 1.41 (< 0.0001), and 1.20 (0.09), respectively. The results reported that just the TT genotype of IL-13 (rs1800925), the T allele and TT genotype of IL-22 (rs2227485), and the G allele and GG, AG and GG + AG genotypes of IL-27 (rs153109) polymorphisms had an elevated risk in CRC patients.
白细胞介素（ILs）在触发血管和免疫细胞的炎症反应中起重要作用。进行了一项系统综述和荟萃分析，以研究白细胞介素-8（rs4073）、白细胞介素-13（rs1800925）、白细胞介素-22（rs1179251、rs1179246和rs2227485）以及白细胞介素-27（rs17855750和rs153109）基因多态性与患结直肠癌（CRC）风险之间的关系。截至2023年10月13日，对四个数据库进行了无限制检索，以查找相关研究。在五个遗传模型中使用粗比值比（ORs）和95%置信区间评估关联。共有23篇文章纳入荟萃分析。白细胞介素-8（rs4073）基因多态性在符合Hardy-Weinberg平衡且无异质性的研究中的合并ORs（p值）分别为0.98（0.63）、0.93（0.44）、0.89（0.13）、0.94（0.38）和0.99（0.90），在所有具有高异质性的研究中的合并ORs分别为1.03（0.69）、1.30（0.07）、1.04（0.71）、1.12（0.20）和1.23（0.06）。对于白细胞介素-13（rs1800925）基因多态性，在AHHDR模型中的合并ORs分别为1.44（0.06）、2.58（0.0004）、1.72（0.16）、1.82（0.09）和2.37（0.001）。白细胞介素-22（rs1179251）基因多态性在AHHDR模型中的合并ORs分别为0.97（0.92）、0.92（0.90）、0.98（p = 0.95）、1.08（0.87）和0.96（0.82）。白细胞介素-22（rs1179246）基因多态性在AHHDR模型中的合并ORs分别为0.98（0.67）、0.97（0.80）、0.92（0.36）、0.93（0.42）和1.02（0.84）。白细胞介素-22（rs2227485）基因多态性在AHHDR模型中的合并ORs分别为1.47（0.02）、2.03（0.02）、1.28（0.29）、1.52（0.06）和1.70（0.04）。白细胞介素-27（rs17855750）基因多态性在AHHDR模型中的合并ORs分别为0.53（0.46）、0.19（0.28）、1.10（0.60）、0.55（0.58）和0.27（p = 0.05）。白细胞介素-27（rs153109）基因多态性在AHHDR模型中的合并ORs分别为1.28（0.007）、1.45（0.002）、1.40（0.0002）、1.41（<0.0001）和1.20（0.09）。结果表明，仅白细胞介素-13（rs1800925）的TT基因型、白细胞介素-22（rs2227485）的T等位基因和TT基因型以及白细胞介素-27（rs153109）基因多态性的G等位基因和GG、AG以及GG + AG基因型在CRC患者中有升高的风险。
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