白细胞介素-8 Rs4073 基因型对台湾三阴性乳腺癌风险的贡献。
The Contribution of Interleukin-8 Rs4073 Genotypes to Triple Negative Breast Cancer Risk in Taiwan.
机构信息
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
出版信息
Anticancer Res. 2022 Aug;42(8):3799-3806. doi: 10.21873/anticanres.15870.
BACKGROUND/AIM: Triple negative breast cancer (TNBC) is one of the most challenging breast cancer types. Interleukin-8 (IL-8) is a pro-tumorigenic cytokine, promoting tumor proliferation and migration. This study aimed to examine the contribution of IL-8 rs4073 genotypes to breast cancer risk and provide a summary of related literature.
MATERIALS AND METHODS
IL-8 genotypic profiles were determined among 1,232 breast cancer cases and 1,232 controls via polymerase chain reaction-restriction fragment length polymorphism methodology.
RESULTS
The IL-8 rs4073 AT and AA genotypes had significantly lower prevalence in the case group compared to control group. Allelic frequency analysis showed that individuals carrying the A allele have relatively decreased risk for breast cancer. The stratification analysis showed that IL-8 rs4073 genotypes were protective markers for those with younger (≤55) age.
CONCLUSION
IL-8 rs4073 A allele is a novel predictor for breast cancer, especially TNBC.
背景/目的：三阴性乳腺癌（TNBC）是最具挑战性的乳腺癌类型之一。白细胞介素-8（IL-8）是一种促肿瘤细胞因子，促进肿瘤增殖和迁移。本研究旨在探讨 IL-8 rs4073 基因型对乳腺癌风险的贡献，并对相关文献进行综述。
材料与方法
采用聚合酶链反应-限制性片段长度多态性方法，对 1232 例乳腺癌病例和 1232 例对照的 IL-8 基因型进行了检测。
结果
与对照组相比，IL-8 rs4073 AT 和 AA 基因型在病例组中的发生率显著降低。等位基因频率分析显示，携带 A 等位基因的个体患乳腺癌的风险相对较低。分层分析显示，IL-8 rs4073 基因型是年龄≤55 岁的患者的保护标志物。
结论
IL-8 rs4073 A 等位基因是乳腺癌的一个新的预测因子，特别是 TNBC。
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