Department of Chemistry, School of Advanced Sciences, VIT, Vellore, 632014, Tamil Nadu, India.
Department of Chemistry, Central Tribal University of Andhra Pradesh, Kondakarakam Village, Cantonment, Vizianagaram, Andhra Pradesh, 535003, India.
Top Curr Chem (Cham). 2024 Nov 15;382(4):36. doi: 10.1007/s41061-024-00482-9.
In the realm of organic synthesis, reagents can serve not only as solvents but also as synthons. Dimethyl sulfoxide (DMSO) is recognized for its efficiency in this dual capacity, enabling diverse chemical transformations. DMSO can generate various synthons, including methyl, methylene, methine, oxygen, and methyl sulfoxide, broadening the accessible compound repertoire. Activation of DMSO as a reagent relies heavily on synergies with secondary agents like peroxide, persulfate, or iodine. Recent years have witnessed a surge in innovative synthetic techniques harnessing the synergistic interplay of DMSO and peroxide, leading to environmentally friendly and cost-effective reactions with mild conditions. This review highlights the synergistic effects of DMSO and peroxides (up to 2023), detailing their activation mechanisms and the generation of various synthons, along with numerous reported derivatives. Although this topic has received considerable attention in recent years, there are numerous discrepancies and a plethora of possibilities yet to be explored. We anticipate that this review will significantly support researchers in advancing their innovations to a greater extent in the future.
在有机合成领域，试剂不仅可以充当溶剂，还可以作为合成子。二甲基亚砜（DMSO）因其在这两种功能上的高效性而备受认可，能够实现多种化学转化。DMSO 可以生成各种合成子，包括甲基、亚甲基、次甲基、氧和甲基亚砜，从而拓宽了可利用的化合物范围。DMSO 作为试剂的激活主要依赖于与过氧化物、过硫酸盐或碘等辅助试剂的协同作用。近年来，利用 DMSO 和过氧化物协同作用的创新合成技术呈爆发式增长，这些技术可实现温和条件下绿色环保且具有成本效益的反应。本综述重点介绍了 DMSO 和过氧化物（截至 2023 年）的协同效应，详细阐述了它们的激活机制和各种合成子的生成，以及大量报道的衍生物。尽管近年来该主题受到了广泛关注，但仍存在许多差异和大量尚未探索的可能性。我们预计，本综述将在未来更大程度上支持研究人员推进他们的创新。
