Phanindrudu Mandalaparthi, Wakade Sandip Balasaheb, Tiwari Dipak Kumar, Likhar Pravin R, Tiwari Dharmendra Kumar
Division of Organic Synthesis and Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Academy of Scientific & Innovative Research (AcSIR) , New Delhi 110001 , India.
J Org Chem. 2018 Aug 17;83(16):9137-9143. doi: 10.1021/acs.joc.8b01204. Epub 2018 Jul 12.
An efficient and transition-metal-free approach for the synthesis of 4-arylquinolines from readily available anilines and alkynes in the presence of KSO and DMSO has been developed. A variety of alkynes and anilines having a diverse range of substitution patterns can undergo the one-pot cascade process successfully. Effectively, this method uses DMSO as one carbon source, thus providing a highly atom-economical and environmentally benign approach for the synthesis of 4-arylquinolines.
已开发出一种高效且无过渡金属的方法，用于在KSO和DMSO存在下，由易得的苯胺和炔烃合成4-芳基喹啉。多种具有不同取代模式的炔烃和苯胺均可成功进行一锅法级联反应。实际上，该方法使用DMSO作为一个碳源，从而为4-芳基喹啉的合成提供了一种高度原子经济且环境友好的方法。
