经颅直流电刺激治疗膝骨关节炎后应答者与无应答者的比较。
Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation.
机构信息
College of Nursing, The University of Arizona, Tucson, AZ, USA.
Department of Statistics Tallahassee, Florida State University, Tallahassee, FL, USA.
出版信息
Pain Manag. 2024 Sep;14(9):507-518. doi: 10.1080/17581869.2024.2429943. Epub 2024 Nov 16.
AIM
The study compared responders and nonresponders to transcranial direct current stimulation (tDCS) regarding clinical pain outcomes in knee osteoarthritis (OA) patients.
PATIENTS AND METHODS/MATERIALS: Sixty participants received home-based active tDCS, and clinical pain outcomes were compared between responders and nonresponders.
RESULTS
Latent class growth analyses classified 41 participants as responders and 19 as nonresponders. Responders showed significantly greater decreases in pain intensity from baseline to post intervention than nonresponders ( < .001). Participants with higher BMI ( = .02) and weight ( = .005) were more likely to respond, while no significant sociodemographic differences were found.
CONCLUSIONS
Identifying characteristics of nonresponsive tDCS subgroups can tailor treatments for each group.
CLINICAL TRIAL REGISTRATION
www.clinicaltrials.gov identifier is NCT04016272.
目的
本研究比较了经颅直流电刺激（tDCS）治疗膝骨关节炎（OA）患者的应答者和无应答者的临床疼痛结局。
患者和方法/材料：60 名参与者接受了家庭式主动 tDCS 治疗，比较了应答者和无应答者之间的临床疼痛结局。
结果
潜在类别增长分析将 41 名参与者分类为应答者，19 名参与者分类为无应答者。与无应答者相比，应答者的疼痛强度从基线到干预后显著降低（ < .001）。体重指数（BMI）较高（ = .02）和体重较大（ = .005）的参与者更有可能产生应答，而没有发现显著的社会人口统计学差异。
结论
确定无应答 tDCS 亚组的特征可以为每个亚组量身定制治疗方案。
临床试验注册
www.clinicaltrials.gov 标识符为 NCT04016272。
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