Neto Marcelo, Mendes Beatriz, Albuquerque Fernando, da Silva José António P
Rheumatology Department, Unidade Local de Saúde de Coimbra, Portugal.
Rheumatology Department, Unidade Local de Saúde de Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Portugal.
Best Pract Res Clin Rheumatol. 2025 Mar;39(1):102021. doi: 10.1016/j.berh.2024.102021. Epub 2024 Nov 16.
Over the past decades our understanding of rheumatoid arthritis (RA) pathogenesis has improved remarkably and major breakthroughs in the treatment of RA were made with the advent of numerous targeted therapies and new treatment strategies. Despite these advances, several unmet needs remain, namely in achieving earlier and more accurate diagnosis, monitoring disease activity, predicting disease prognosis and optimizing treatment. To address these gaps, recent research has focused on identifying biomarkers that may enhance diagnostic precision, predict disease prognosis, and optimize treatment strategies. In this narrative review we will describe recent developments in RA biomarkers with demonstrated or promising clinical relevance.
在过去几十年里，我们对类风湿关节炎（RA）发病机制的理解有了显著提高，随着众多靶向治疗和新治疗策略的出现，RA治疗取得了重大突破。尽管有这些进展，但仍存在一些未满足的需求，即在实现更早、更准确的诊断、监测疾病活动、预测疾病预后和优化治疗方面。为了填补这些空白，最近的研究集中在识别可能提高诊断精度、预测疾病预后和优化治疗策略的生物标志物。在这篇叙述性综述中，我们将描述RA生物标志物的最新进展，这些进展已显示出或有望具有临床相关性。
