• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Are oligodendrocytes the missing link in Alzheimer's disease and related dementia research?

作者信息

Rossi Sharyn L, Bovenkamp Diane E

机构信息

BrightFocus Foundation, 22512 Gateway Center Drive, Clarksburg, MD, 20871, USA.

出版信息

Mol Neurodegener. 2024 Nov 17;19(1):84. doi: 10.1186/s13024-024-00760-6.

DOI:10.1186/s13024-024-00760-6
PMID:39550555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11569602/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a5/11569602/d1853494aa66/13024_2024_760_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a5/11569602/d1853494aa66/13024_2024_760_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a5/11569602/d1853494aa66/13024_2024_760_Fig1_HTML.jpg

相似文献

1
Are oligodendrocytes the missing link in Alzheimer's disease and related dementia research?少突胶质细胞是阿尔茨海默病及相关痴呆症研究中缺失的环节吗?
Mol Neurodegener. 2024 Nov 17;19(1):84. doi: 10.1186/s13024-024-00760-6.
2
Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease.棕榈酸酯和葡萄糖增加细胞外囊泡中的淀粉样前体蛋白:代谢综合征与阿尔茨海默病之间缺失的环节。
J Extracell Vesicles. 2023 Nov;12(11):e12340. doi: 10.1002/jev2.12340.
3
Alzheimer's disease research in the context of the national plan to address Alzheimer's disease.在国家应对阿尔茨海默病计划的背景下进行阿尔茨海默病研究。
Mol Aspects Med. 2015 Jun-Oct;43-44:16-24. doi: 10.1016/j.mam.2015.06.005. Epub 2015 Jun 18.
4
Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project.探究衰弱在阿尔茨海默病神经病理学与痴呆关系中的调节作用:来自拉什记忆和衰老项目的横断面数据分析。
Lancet Neurol. 2019 Feb;18(2):177-184. doi: 10.1016/S1474-4422(18)30371-5.
5
Cancer diagnosis is associated with a lower burden of dementia and less Alzheimer's-type neuropathology.癌症诊断与痴呆症负担降低和较少的阿尔茨海默病型神经病理学相关。
Brain. 2022 Jul 29;145(7):2518-2527. doi: 10.1093/brain/awac035.
6
Nimodipine for primary degenerative, mixed and vascular dementia.尼莫地平用于原发性退行性、混合型和血管性痴呆。
Cochrane Database Syst Rev. 2002(3):CD000147. doi: 10.1002/14651858.CD000147.
7
Serum autoantibodies in patients with Alzheimer's disease and vascular dementia and in nondemented control subjects.阿尔茨海默病和血管性痴呆患者以及非痴呆对照受试者的血清自身抗体。
Stroke. 1992 Aug;23(8):1078-83. doi: 10.1161/01.str.23.8.1078.
8
Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study.未控制的糖尿病会增加患阿尔茨海默病的风险:一项基于人群的队列研究。
Diabetologia. 2009 Jun;52(6):1031-9. doi: 10.1007/s00125-009-1323-x. Epub 2009 Mar 12.
9
The micron stroke hypothesis of Alzheimer's disease and dementia.阿尔茨海默病和痴呆的微卒中风假说。
Med Hypotheses. 2012 May;78(5):562-70. doi: 10.1016/j.mehy.2012.01.020. Epub 2012 Feb 29.
10
Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies.血管性痴呆、阿尔茨海默病和路易体痴呆患者额叶白质髓鞘丢失的定量研究。
Acta Neuropathol. 2010 May;119(5):579-89. doi: 10.1007/s00401-009-0635-8. Epub 2010 Jan 21.

引用本文的文献

1
Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease.少突胶质细胞功能障碍在阿尔茨海默病进展中的新作用。
J Neuroimmune Pharmacol. 2025 Sep 1;20(1):79. doi: 10.1007/s11481-025-10236-z.
2
Integrated multi-omics analyses of synaptosomes revealed synapse-associated novel targets in Alzheimer's disease.对突触体的综合多组学分析揭示了阿尔茨海默病中与突触相关的新靶点。
Mol Psychiatry. 2025 Jun 28. doi: 10.1038/s41380-025-03095-w.
3
THE MODULATION OF THE BLOOD-BRAIN BARRIER BY FOCUSED ULTRASOUND STIMULATES OLIGODENDROGENESIS.

本文引用的文献

1
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer's disease.阿尔茨海默病小鼠模型中少突胶质细胞淀粉样沉积的贡献。
Mol Neurodegener. 2024 Nov 16;19(1):83. doi: 10.1186/s13024-024-00759-z.
2
Integrated multimodal cell atlas of Alzheimer's disease.阿尔茨海默病的综合多模态细胞图谱。
Nat Neurosci. 2024 Dec;27(12):2366-2383. doi: 10.1038/s41593-024-01774-5. Epub 2024 Oct 14.
3
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
聚焦超声对血脑屏障的调节可促进少突胶质细胞生成。
bioRxiv. 2025 May 22:2025.05.21.655298. doi: 10.1101/2025.05.21.655298.
少突胶质细胞产生淀粉样β蛋白,并与阿尔茨海默病模型小鼠中的神经元一起促进斑块形成。
Nat Neurosci. 2024 Sep;27(9):1668-1674. doi: 10.1038/s41593-024-01730-3. Epub 2024 Aug 5.
4
The role of myelin in neurodegeneration: implications for drug targets and neuroprotection strategies.髓鞘在神经退行性变中的作用:对药物靶点和神经保护策略的影响。
Rev Neurosci. 2023 Nov 22;35(3):271-292. doi: 10.1515/revneuro-2023-0081. Print 2024 Apr 25.
5
Early Alzheimer's disease pathology in human cortex involves transient cell states.人类大脑皮层中的早发性阿尔茨海默病病理学涉及短暂的细胞状态。
Cell. 2023 Sep 28;186(20):4438-4453.e23. doi: 10.1016/j.cell.2023.08.005.
6
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.脑脊液蛋白质组学定义常染色体显性阿尔茨海默病的自然史。
Nat Med. 2023 Aug;29(8):1979-1988. doi: 10.1038/s41591-023-02476-4. Epub 2023 Aug 7.
7
NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss.NF-κB 是少突胶质细胞有丝分裂后衰老和随后的白质丢失的关键介质。
Mol Neurodegener. 2023 Apr 17;18(1):24. doi: 10.1186/s13024-023-00616-5.
8
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.载脂蛋白 E4 通过调控少突胶质细胞胆固醇影响髓鞘形成。
Nature. 2022 Nov;611(7937):769-779. doi: 10.1038/s41586-022-05439-w. Epub 2022 Nov 16.
9
Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics.阿尔茨海默病中的髓鞘修复:生物途径和潜在治疗方法的综述。
Transl Neurodegener. 2022 Oct 26;11(1):47. doi: 10.1186/s40035-022-00321-1.
10
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice.少突胶质前体细胞在小鼠回路重塑过程中吞噬突触。
Nat Neurosci. 2022 Oct;25(10):1273-1278. doi: 10.1038/s41593-022-01170-x. Epub 2022 Sep 28.