Khalilov E M, Ivanova L I
Biofizika. 1986 Jan-Feb;31(1):156-7.
It is shown that cholesterol incorporation into the membranes of Zajdel hepatoma cells, lymphoblast leukemia cells L1210 and into those of ovary tumour causes an increase in the membrane phospholipid bilayer microviscosity measured by pyrene as fluorescent probe. The increase in the membrane lipid microviscosity resulted in a decrease in the activity of Na,K-ATPase and 5-nucleotidase of the tumour cells. After the injection of tumour cells with an increase of cholesterol/phospholipid ratio we observed an increase of the life-span of experimental animals as compared to the control groups.
结果表明，将胆固醇掺入扎伊德尔肝癌细胞、淋巴母细胞白血病细胞L1210以及卵巢肿瘤细胞的细胞膜中，会导致以芘作为荧光探针测得的膜磷脂双分子层微粘度增加。膜脂质微粘度的增加导致肿瘤细胞的钠钾ATP酶和5-核苷酸酶活性降低。在用胆固醇/磷脂比率增加的肿瘤细胞进行注射后，我们观察到与对照组相比，实验动物的寿命有所延长。
