Hollensteiner Marianne, Baumeister Dirk, Mühling Mischa, Greinwald Markus, Sandriesser Sabrina, Hofstätter Bernhard, Petersik Andreas, Augat Peter
Institute for Biomechanics, BG Unfallklinik Murnau, Prof. Küntscher Str. 8, 82418 Murnau, Germany; Institute for Biomechanics, Paracelsus Medical University Salzburg, Strubergasse 21, 5020 Salzburg, Austria.
Institute for Biomechanics, BG Unfallklinik Murnau, Prof. Küntscher Str. 8, 82418 Murnau, Germany; Institute for Biomechanics, Paracelsus Medical University Salzburg, Strubergasse 21, 5020 Salzburg, Austria.
Clin Biomech (Bristol). 2025 Jan;121:106379. doi: 10.1016/j.clinbiomech.2024.106379. Epub 2024 Nov 14.
Biomechanical testing using synthetic bone surrogates has become a standard method for evaluating osteosynthesis techniques. However, these surrogates often fail to account for population-specific variations in bone anatomy and mechanical properties, leading to limitations in predicting clinical outcomes. This study addresses this gap by developing and validating a population-specific synthetic femur model for older women of European ethnicity, incorporating variations in geometry and mechanics observed in this demographic.
The femur model was developed using a statistical shaping algorithm and 3D models from women aged 75 to 85 years. Synthetic femora were fabricated using polyurethane, enriched with fillers and additives to mimic osteoporotic bone characteristics. Mechanical testing, including axial compression, four-point bending, and torsion, was performed on synthetic femora and were validated against human osteoporotic femora.
The synthetic femora demonstrated comparable mechanical properties to human osteoporotic femora, particularly in flexural and torsional rigidity. Axial stiffness was slightly lower in the synthetic femora but remained within the range of literature values. Statistical analysis revealed significant differences between synthetic and human bones in certain parameters, highlighting the need for population-specific models.
The developed synthetic femur model offers a promising solution for addressing the limitations of current bone surrogates in biomechanical testing. By incorporating population-specific characteristics these models provide a more accurate representation of human bone, improving the validity of biomechanical evaluations and potentially leading to more equitable treatment outcomes in orthopaedics. Further research is warranted to explore the applicability of these models across different populations and anatomical sites.
使用合成骨替代物进行生物力学测试已成为评估骨固定技术的标准方法。然而，这些替代物往往未能考虑到人群特异性的骨解剖结构和力学性能差异，导致在预测临床结果方面存在局限性。本研究通过开发和验证针对欧洲族裔老年女性的人群特异性合成股骨模型来填补这一空白，该模型纳入了在这一人群中观察到的几何形状和力学方面的差异。
使用统计塑形算法和75至85岁女性的3D模型开发股骨模型。使用聚氨酯制造合成股骨，并添加填充剂和添加剂以模拟骨质疏松性骨的特征。对合成股骨进行了包括轴向压缩、四点弯曲和扭转在内的力学测试，并与人类骨质疏松性股骨进行了验证。
合成股骨表现出与人类骨质疏松性股骨相当的力学性能，特别是在弯曲和扭转刚度方面。合成股骨的轴向刚度略低，但仍在文献值范围内。统计分析揭示了合成骨与人类骨在某些参数上存在显著差异，凸显了人群特异性模型的必要性。
所开发的合成股骨模型为解决当前骨替代物在生物力学测试中的局限性提供了一个有前景的解决方案。通过纳入人群特异性特征，这些模型能更准确地代表人类骨骼，提高生物力学评估的有效性，并可能在骨科领域带来更公平的治疗结果。有必要进一步开展研究，以探索这些模型在不同人群和解剖部位的适用性。
