Song Zhixing, Balachandra Sanjana, Wu Christopher, Akhund Ramsha, Fazendin Jessica, Lindeman Brenessa, Chen Herbert, Gillis Andrea
Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee.
Endocr Pract. 2025 Feb;31(2):169-175. doi: 10.1016/j.eprac.2024.11.005. Epub 2024 Nov 16.
Inadequate surveillance of thyroid nodules can lead to cancer progression. This study examines patient characteristics that correlate with failure to follow up after thyroid nodule detection.
We performed a retrospective analysis of patients who underwent fine needle aspiration for thyroid nodules and studied subsequent thyroid ultrasounds, clinic visits, and thyroidectomies longitudinally. Poverty areas are census tracts where at least 20% of residents live below the poverty line. Logistic regression was used to assess associations between patient characteristics and follow-ups, with results expressed as odds ratios (ORs) and 95% CIs.
Of 2446 patients included, the majority were White (62.6%) and female (78.5%), with an average age of 55 ± 16 years. 28% patients were from high poverty areas. Benign findings (Bethesda II) were observed in 73.5% of the biopsies. 42.5% of patients underwent at least one follow-up ultrasound, 59% had at least one clinic visit, and 24.4% underwent a thyroidectomy, with a 34.8% malignancy rate on surgical pathology. Patients from high poverty areas were significantly less likely to receive follow-up ultrasounds (35.7% vs 45.9%, P < .001) or clinic visits (53.7% vs 61.2%, P = .001). Multivariable analysis revealed that poverty was significantly associated with not having follow-up in all patients (OR = 0.78, 95% CI 0.64-0.96) and non-benign biopsy (Bethesda 3 or higher) results (OR = 0.44, 95% CI 0.24-0.81).
There is a notable disparity in the follow-up of thyroid nodules, with patients from high poverty areas being more susceptible to loss of follow-ups.
对甲状腺结节的监测不足可能导致癌症进展。本研究调查了与甲状腺结节检测后未进行后续随访相关的患者特征。
我们对接受甲状腺结节细针穿刺的患者进行了回顾性分析,并纵向研究了随后的甲状腺超声检查、门诊就诊和甲状腺切除术。贫困地区是指至少20%的居民生活在贫困线以下的普查区。采用逻辑回归分析评估患者特征与随访之间的关联,结果以比值比(OR)和95%置信区间(CI)表示。
纳入的2446例患者中,大多数为白人(62.6%)和女性(78.5%),平均年龄为55±16岁。28%的患者来自高贫困地区。73.5%的活检结果为良性(贝塞斯达二级)。42.5%的患者至少接受了一次随访超声检查,59%的患者至少进行了一次门诊就诊,24.4%的患者接受了甲状腺切除术,手术病理的恶性率为34.8%。来自高贫困地区的患者接受随访超声检查(35.7%对45.9%,P<.001)或门诊就诊(53.7%对61.2%,P=.001)的可能性显著降低。多变量分析显示,贫困与所有患者未进行随访(OR=0.78,95%CI 0.64-0.96)和非良性活检(贝塞斯达3级或更高)结果(OR=0.44,95%CI 0.24-0.81)显著相关。
甲状腺结节的随访存在显著差异,来自高贫困地区的患者更容易失去随访。