Rafi Halima, Samson Jessica Lee, Rudloff Juan Barrios, Poznyak Elena, Gauthey Melissa, Perroud Nader, Debbané Martin
Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Developmental Neuroimaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland.
Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Developmental Neuroimaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland.
J Affect Disord. 2025 Mar 1;372:86-95. doi: 10.1016/j.jad.2024.11.036. Epub 2024 Nov 15.
This study assessed adolescent brain-behavior relationships between large-scale dynamic functional network connectivity (FNC) and an integrated attention-deficit/hyperactivity disorder (ADHD) phenotype, including measures of inattention, impulsivity/hyperactivity and emotional dysregulation. Despite emotion dysregulation being a core clinical feature of ADHD, studies rarely assess its impact on large-scale FNC.
We conducted resting-state functional magnetic resonance imaging in 78 adolescents (34 with ADHD) and obtained experimental and self-reported measures of inattention, impulsivity/hyperactivity, and emotional reactivity. We used multivariate analyses to evaluate group differences in dynamic FNC between the default mode, salience and central executive networks, meta-state functional connectivity and ADHD symptomology.
We present two significant group*behavior effects. Compared to controls, adolescents with ADHD had 1) diminished salience network-centered dynamic FNC that was driven by an integrated ADHD phenotype (p < .004, r = 0.57) and 2) more variable patterns of global connectivity, as measured through meta-state analysis, which were driven by heightened emotional reactivity (p < .002, r = 0.63).
Atypical patterns of dynamic FNC in adolescents with ADHD are associated with the affective and cognitive components of ADHD symptomology. Limitations include sample size and self-reported measures of emotional reactivity.
本研究评估了青少年大脑与行为之间的关系，涉及大规模动态功能网络连接性（FNC）与注意力缺陷多动障碍（ADHD）综合表型，包括注意力不集中、冲动/多动和情绪失调的测量指标。尽管情绪失调是ADHD的核心临床特征，但研究很少评估其对大规模FNC的影响。
我们对78名青少年（34名患有ADHD）进行了静息态功能磁共振成像，并获得了注意力不集中、冲动/多动和情绪反应性的实验性和自我报告测量指标。我们使用多变量分析来评估默认模式、突显网络和中央执行网络之间动态FNC的组间差异、元状态功能连接性和ADHD症状学。
我们呈现了两个显著的组*行为效应。与对照组相比，患有ADHD的青少年有1）以突显网络为中心的动态FNC减弱，这是由ADHD综合表型驱动的（p <.004，r = 0.57），以及2）通过元状态分析测量的全局连接性模式更具变异性，这是由增强的情绪反应性驱动的（p <.002，r = 0.63）。
患有ADHD的青少年动态FNC的非典型模式与ADHD症状学的情感和认知成分相关。局限性包括样本量和情绪反应性的自我报告测量指标。
