Division of Cardiology, Department of Medicine, University of California, Los Angeles, 650 Charles E. Young Dr. South, A2-237 CHS, Los Angeles, CA 90095, USA.
Division of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, 550 Robinson Research Building, Nashville, TN 37232, USA.
Cardiol Clin. 2025 Feb;43(1):13-23. doi: 10.1016/j.ccl.2024.08.004. Epub 2024 Oct 2.
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon in which somatic mutations lead to clonal expansion of hematopoietic stem cells without the development of hematologic abnormalities. A growing body of literature demonstrates an association between CHIP and cardiovascular disease. This pathophysiology demonstrates a novel connection between global inflammation and cardiovascular morbidity. While there is limited consensus addressing the cardiovascular care of these patients, risk factor optimization and disease surveillance are advisable. Investigation into possible therapies is ongoing and provides promise for the treatment of inflammation contributing to cardiovascular disease in patients with and without CHIP.
克隆性造血（CHIP）是一种与年龄相关的现象，其中体细胞突变导致造血干细胞的克隆性扩张，而没有血液学异常的发展。越来越多的文献表明 CHIP 与心血管疾病之间存在关联。这种病理生理学显示了全身炎症与心血管发病率之间的新联系。虽然针对这些患者的心血管护理存在有限的共识，但建议优化风险因素和疾病监测。正在进行对可能的治疗方法的研究，并为治疗伴有和不伴有 CHIP 的心血管疾病患者的炎症提供了希望。
