• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Y染色体解读的相关命题。

Relevant propositions for Y chromosome interpretation.

作者信息

Bright Jo-Anne, Andersen Mikkel Meyer, Taylor Duncan, Kelly Hannah, Kruijver Maarten, Buckleton John

机构信息

Institute of Environmental Science and Research Limited, Auckland, New Zealand.

Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark.

出版信息

J Forensic Sci. 2025 Jan;70(1):271-275. doi: 10.1111/1556-4029.15669. Epub 2024 Nov 17.

DOI:10.1111/1556-4029.15669
PMID:39552024
Abstract

The Y chromosomal haplotype is expected to be identical (or close to, depending on the mutation rate) among a male and many of his paternal relatives. This means that often the same evidential value for the DNA evidence is obtained, whether the true donor or one of his close paternal relatives is compared to a crime sample. Commentators (see for example the UK Forensic Science Regulator or Amorim) have suggested to change the proposition pair to compare the probability of the evidence if the Person of Interest (POI) or one of his close paternal relatives left the DNA to the probability of the evidence if an unrelated male from the population left the DNA. We argue that this is problematic because there is no clear definition of close paternal relatives and truly unrelated males do not exist. Instead, we take a starting point in the traditional proposition pair "The source of the male DNA is the POI" versus "The source of the male DNA is not the POI" and make the latter one operational by suggesting that it is formulated as "The source of the male DNA is a random man from the population". The issue of matching males in the POI's lineage is then addressed either in a comment in the statement or directly through a probability model.

摘要

在男性及其许多父系亲属中,Y染色体单倍型预计是相同的(或接近相同,这取决于突变率)。这意味着,无论将真正的DNA提供者还是其近亲父系亲属之一与犯罪样本进行比对,通常都会获得相同的DNA证据价值。评论者(例如英国法医学监管机构或阿莫林)建议更改命题对,即比较如果犯罪嫌疑人(POI)或其近亲父系亲属之一留下了DNA,证据出现的概率与如果人群中一个无关男性留下了DNA,证据出现的概率。我们认为这存在问题,因为近亲父系亲属没有明确的定义,而且真正无关的男性并不存在。相反,我们以传统的命题对“男性DNA的来源是犯罪嫌疑人”与“男性DNA的来源不是犯罪嫌疑人”为出发点,并通过建议将后者表述为“男性DNA的来源是人群中的一个随机男性”来使其具有可操作性。然后,要么在陈述中的注释里,要么直接通过概率模型来解决犯罪嫌疑人谱系中男性匹配的问题。

相似文献

1
Relevant propositions for Y chromosome interpretation.Y染色体解读的相关命题。
J Forensic Sci. 2025 Jan;70(1):271-275. doi: 10.1111/1556-4029.15669. Epub 2024 Nov 17.
2
Comparing multiple POI to DNA mixtures.比较多个 POI 与 DNA 混合物。
Forensic Sci Int Genet. 2021 May;52:102481. doi: 10.1016/j.fsigen.2021.102481. Epub 2021 Feb 9.
3
Y-profile evidence: Close paternal relatives and mixtures.Y 系谱证据:近亲关系和混合。
Forensic Sci Int Genet. 2019 Jan;38:48-53. doi: 10.1016/j.fsigen.2018.10.004. Epub 2018 Oct 10.
4
Forensic use of Y-chromosome DNA: a general overview.Y染色体DNA的法医学应用:综述
Hum Genet. 2017 May;136(5):621-635. doi: 10.1007/s00439-017-1776-9. Epub 2017 Mar 17.
5
A new future of forensic Y-chromosome analysis: rapidly mutating Y-STRs for differentiating male relatives and paternal lineages.法医 Y 染色体分析的新未来:快速突变的 Y-STR 用于区分男性亲属和父系血统。
Forensic Sci Int Genet. 2012 Mar;6(2):208-18. doi: 10.1016/j.fsigen.2011.04.017. Epub 2011 May 25.
6
DNA commission of the International Society of Forensic Genetics (ISFG): Recommendations on the interpretation of Y-STR results in forensic analysis.国际法庭遗传学家学会(ISFG)DNA 委员会:法庭分析中 Y-STR 结果解读的建议。
Forensic Sci Int Genet. 2020 Sep;48:102308. doi: 10.1016/j.fsigen.2020.102308. Epub 2020 Jun 4.
7
Improving the differentiation of closely related males by RMplex analysis of 30 Y-STRs with high mutation rates.通过对30个高突变率Y染色体短串联重复序列(Y-STR)进行RMplex分析,提高亲缘关系相近男性个体的鉴别能力。
Forensic Sci Int Genet. 2022 May;58:102682. doi: 10.1016/j.fsigen.2022.102682. Epub 2022 Feb 24.
8
How convincing is a matching Y-chromosome profile?匹配的Y染色体图谱有多令人信服?
PLoS Genet. 2017 Nov 3;13(11):e1007028. doi: 10.1371/journal.pgen.1007028. eCollection 2017 Nov.
9
Y chromosome STR typing in crime casework.犯罪案件工作中的Y染色体短串联重复序列分型
Forensic Sci Med Pathol. 2009;5(2):77-84. doi: 10.1007/s12024-009-9089-5. Epub 2009 May 20.
10
Likelihood ratio development for mixed Y-STR profiles.混合 Y-STR 谱的似然比发展。
Forensic Sci Int Genet. 2018 Jul;35:82-96. doi: 10.1016/j.fsigen.2018.03.006. Epub 2018 Apr 7.

引用本文的文献

1
Recent Statistical Innovations in Human Genetics.人类遗传学领域的最新统计创新
Ann Hum Genet. 2025 Sep;89(5):241-254. doi: 10.1111/ahg.12606. Epub 2025 Jun 27.
2
On forensic likelihood ratios from low-coverage sequencing.关于低覆盖度测序的法医似然比
Forensic Sci Int Genet. 2025 Sep;79:103302. doi: 10.1016/j.fsigen.2025.103302. Epub 2025 May 27.