Burov Iu V, Kampov-Polevoĭ A V, Nikitina L N
Biull Eksp Biol Med. 1986 Mar;101(3):289-91.
The experiments have shown the capacity of antidepressant amitriptylin (0.5 mg/kg, i. p.) and tranquilizer phenazepam (0.1 mg/kg i. p.) to normalize the adaptive behaviour and almost completely prevent the development of alcohol motivation in animals with insufficient adaptive behaviour. It was established that in animals initially rejecting alcohol, chronic treatment with these drugs as well as d-amphetamine promoted alcohol motivation. The results obtained have proved our earlier hypothesis that preclinical search for drugs for the prevention and treatment of early stages of alcoholism is possible only in animals pre-selected according to their inclination to experimental alcoholism.
实验表明，抗抑郁药阿米替林（0.5毫克/千克，腹腔注射）和镇静剂非那西泮（0.1毫克/千克，腹腔注射）能够使适应行为正常化，并几乎完全阻止适应行为不足的动物产生酒精动机。已确定，在最初拒绝酒精的动物中，用这些药物以及右旋苯丙胺进行长期治疗会促进酒精动机。所获得的结果证明了我们之前的假设，即只有在根据实验性酒精中毒倾向预先选择的动物中，才有可能进行预防和治疗酒精中毒早期阶段药物的临床前研究。
