Yan Han, Lan Gongbin, Peng Qi, Zhang Wei, Wang Ying, Li Xi
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P.R. China.
Department of Kidney Transplantation, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P.R. China.
Future Microbiol. 2025 Jan;20(1):23-31. doi: 10.1080/17460913.2024.2417608. Epub 2024 Nov 18.
Transplant rejection and failure are the primary causes of shortened lifespan in transplant patients and are closely associated with the status of the human immune system. Gut microbiota have the capacity to modulate the human immune system. However, it remains unclear whether any gut microbiota can influence the risk of transplant failure. A Mendelian randomization study was conducted to explore the causal relationship between gut microbiota and transplant failure. This study utilized three Genome-Wide Association Study results focusing on the gut microbiome, transplant failure and transplantation status. Single nucleotide polymorphisms that were strongly associated with gut microbiota abundance were selected as instrumental variables. The abundance of demonstrated a significant causal relationship with transplant failure (inverse variance weighted [IVW] = 0.049, OR = 0.658, 95% CI: 0.433-0.998), but was not related to the risk of transplantation status (IVW > 0.200). Notably, a higher intestinal abundance of corresponded to a decreased risk of transplant failure. instrumental variables were enriched in pathways related to synapses and membranes. The may play a crucial role in the mechanism of transplant failure. These study results contribute to elucidating the mechanisms underlying transplant failure.
移植排斥和失败是移植患者寿命缩短的主要原因，并且与人体免疫系统的状态密切相关。肠道微生物群有调节人体免疫系统的能力。然而，尚不清楚是否有任何肠道微生物群会影响移植失败的风险。进行了一项孟德尔随机化研究，以探讨肠道微生物群与移植失败之间的因果关系。本研究利用了三项全基因组关联研究结果，分别聚焦于肠道微生物组、移植失败和移植状态。与肠道微生物群丰度密切相关的单核苷酸多态性被选为工具变量。[具体微生物名称未给出]的丰度与移植失败存在显著因果关系（逆方差加权[IVW]=0.049，OR=0.658，95%CI：0.433 - 0.998），但与移植状态的风险无关（IVW>0.200）。值得注意的是，[具体微生物名称未给出]在肠道中的丰度越高，移植失败的风险越低。工具变量在与突触和膜相关的通路中富集。[具体微生物名称未给出]可能在移植失败的机制中起关键作用。这些研究结果有助于阐明移植失败的潜在机制。
