Chen Yaozhu J, Patel Milan, Venkatesan Thangam
Astra Zeneca Outcomes Researcher, USA.
Medical Student, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Neurogastroenterol Motil. 2025 Mar;37(3):e14910. doi: 10.1111/nmo.14910. Epub 2024 Nov 18.
Cyclic vomiting syndrome is a chronic disorder of gut-brain interaction that is present in both adults and children. It is characterized by severe nausea, vomiting, abdominal pain, and several non-GI symptoms. It is also associated with several comorbid conditions such as anxiety and depression, which affect overall health care outcomes.
This article delineates treatment principles, encompassing both abortive interventions and prophylactic regimens currently recommended for CVS. However, it underscores a critical concern: the absence of FDA-approved medications for CVS treatment, with existing therapies relying on retrospective and open-labeled trials.
This article emphasizes the pressing need for the development of CVS-specific outcome assessment tools to facilitate more accurate evaluation and robust data collection for the future studies. In exploring this deficiency, the manuscript also presents the up-to-date data and development that enhances our comprehension of patient-centric concepts, and the challenges faced in creating CVS-specific tools, and presents a roadmap for their development. Addressing this gap is crucial for advancing our understanding of CVS and optimizing patient care.
This elucidates the current state of CVS management but also advocates for a future where tailored tools enhance our ability to measure and improve the outcomes for individuals with this debilitating disorder.
周期性呕吐综合征是一种成人和儿童均会出现的肠脑交互慢性疾病。其特征为严重恶心、呕吐、腹痛以及多种非胃肠道症状。它还与多种共病相关，如焦虑和抑郁，这些会影响整体医疗保健结果。
本文阐述了治疗原则，涵盖目前推荐用于周期性呕吐综合征的终止发作干预措施和预防性治疗方案。然而，它强调了一个关键问题：缺乏美国食品药品监督管理局批准用于治疗周期性呕吐综合征的药物，现有疗法依赖回顾性和开放标签试验。
本文强调迫切需要开发针对周期性呕吐综合征的结局评估工具，以便为未来研究促进更准确的评估和有力的数据收集。在探讨这一不足时，该手稿还展示了最新数据和进展，这些增强了我们对以患者为中心概念的理解，以及创建针对周期性呕吐综合征工具时面临的挑战，并提出了其开发路线图。弥补这一差距对于推进我们对周期性呕吐综合征的理解和优化患者护理至关重要。
这不仅阐明了周期性呕吐综合征管理的现状，还倡导未来有定制工具来增强我们测量和改善患有这种使人衰弱疾病个体结局的能力。
