前蛋白转化酶枯草溶菌素9（PCSK9）蛋白不一定是重度抑郁症的危险因素。
The PCSK9 Protein Is Not Necessarily a Risk Factor for Major Depressive Disorder.
作者信息
Habibitabar Elahe, Khanverdiloo Shima, Doostizadeh Mona, Jahangard Leila, Karimi Jamshid, Shafiee Gholamreza
机构信息
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Psychiatry, Behavioral Disorders and Substance Abuse Research Center, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Basic Clin Neurosci. 2024 Jul-Aug;15(4):519-530. doi: 10.32598/bcn.2022.4044.1. Epub 2024 Jul 1.
INTRODUCTION
Major depressive disorder (MDD) is one of the common psychiatric disorders that is characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) is important in cholesterol homeostasis.
METHODS
This study aimed to investigate PCSK9 levels and oxidative stress with MDD disease. The study included 30 patients with MDD and 30 healthy controls. Their blood samples were collected in sterile tubes, and the serum PCSK9 concentration, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity were determined by ELISA kits. Total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and copper concentration were determined manually. There was a significant increase in PCSK9 levels in the patient group (P<0.05).
RESULTS
The receiver operating characteristic (ROC) curve with a sensitivity of 57% and specificity of 52% was 0.928 (95% CI, 0.86-0.996) for PCSK9 in the patient group (P<0.001). It was found that MDA (P=0.036) level was higher in the MDD group, but TAC (P=0.445) level, SOD (P=0.148), GPx (P=0.019) activities, and copper concentration were lower in the patient group compared with the control group.
CONCLUSION
The study results confirm the relationship between oxidative stress and MDD and also suggest a link between PCSK9 and MDD disease.
引言
重度抑郁症（MDD）是常见的精神疾病之一，其特征为神经生物学反应异常。前蛋白转化酶枯草溶菌素/kexin 9（PCSK9）在胆固醇稳态中起重要作用。
方法
本研究旨在调查MDD患者的PCSK9水平和氧化应激情况。该研究纳入了30例MDD患者和30名健康对照者。他们的血样采集于无菌试管中，采用酶联免疫吸附测定（ELISA）试剂盒测定血清PCSK9浓度、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性。手动测定总抗氧化能力（TAC）、总氧化状态（TOS）、丙二醛（MDA）和铜浓度。患者组的PCSK9水平显著升高（P<0.05）。
结果
患者组PCSK9的受试者工作特征（ROC）曲线的灵敏度为57%，特异性为52%，曲线下面积为0.928（95%CI，0.86 - 0.996）（P<0.001）。发现MDD组的MDA水平较高（P = 0.036），但与对照组相比，患者组的TAC水平（P = 0.445）、SOD活性（P = 0.148）、GPx活性（P = 0.019）和铜浓度较低。
结论
研究结果证实了氧化应激与MDD之间的关系，也提示了PCSK9与MDD疾病之间的联系。
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