Lee Sheng-Yu, Li Sung-Chou, Wang Tzu-Yun, Lu Ru-Band, Wang Liang-Jen, Tsai Kuo-Wang
Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, 813414, Taiwan.
Department of Psychiatry, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
BMC Psychiatry. 2025 Jul 1;25(1):639. doi: 10.1186/s12888-025-07104-8.
In our previous research, we identified five candidate proteins-Carbonic Anhydrase 1 (CA-1), Matrix Metallopeptidase 9 (MMP9), Peroxiredoxin 2 (PRDX2), Phenylalanyl-tRNA Synthetase Subunit Beta (FARSB), and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)-as prospective biomarkers for bipolar II disorder (BD-II). In this study, we explored the relationships between these potential plasma proteins and cognitive performance in BD-II patients using the Brief Assessment of Cognition in Affective Disorders (BACA), a validated tool for assessing cognitive deficits in mood disorders.
One hundred and seventeen participants with BD-II and 41 controls participated in this study. Plasma concentrations of the aforementioned proteins were measured, and cognitive performance was evaluated using the BACA.
Our findings indicated that the BD-II group scored significantly lower than the control group across several BACA subtests, including Digit Sequencing, Symbol Coding, Verbal Memory, and Verbal Fluency, and in overall composite scores and all subtests of the Affective Interference Test (AIT) and Emotion Inhibition Test (EIT). Notably, we observed significant correlations in the BD-II group between levels of CA-1 (r = -0.26, P = 0.005), FARSB (r = 0.399, P < 0.001), and MMP9 (r = 0.24, P = 0.008) with the AIT-Cued affective words subtest. In contrast, a significant correlation was found between the Symbol Coding task and PCSK9 levels (r = 0.35, P = 0.003) in the control group, but not in the BD-II group.
These findings offer new perspectives on the underlying mechanisms contributing to cognitive decline in individuals with BD-II.
在我们之前的研究中，我们确定了五种候选蛋白——碳酸酐酶1（CA-1）、基质金属蛋白酶9（MMP9）、过氧化物酶2（PRDX2）、苯丙氨酰-tRNA合成酶β亚基（FARSB）和前蛋白转化酶枯草溶菌素/克尔新9型（PCSK9）——作为双相II型障碍（BD-II）的潜在生物标志物。在本研究中，我们使用情感障碍认知简短评估（BACA）这一评估情绪障碍认知缺陷的有效工具，探讨了这些潜在血浆蛋白与BD-II患者认知表现之间的关系。
117名BD-II患者和41名对照参与了本研究。测量了上述蛋白的血浆浓度，并使用BACA评估认知表现。
我们的研究结果表明，BD-II组在几个BACA子测试中的得分显著低于对照组，包括数字序列、符号编码、言语记忆和言语流畅性，以及在情感干扰测试（AIT）和情绪抑制测试（EIT）的总体综合得分和所有子测试中。值得注意的是，我们在BD-II组中观察到CA-1水平（r = -0.26，P = 0.005）、FARSB水平（r = 0.399，P < 0.001）和MMP9水平（r = 0.24，P = 0.008）与AIT-提示情感词子测试之间存在显著相关性。相比之下，对照组中符号编码任务与PCSK9水平之间存在显著相关性（r = 0.35，P = 0.003），而BD-II组中未发现这种相关性。
这些发现为BD-II患者认知衰退的潜在机制提供了新的视角。
