Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, P.O. Box: 196, Gondar, Ethiopia.
BMC Res Notes. 2023 Aug 31;16(1):191. doi: 10.1186/s13104-023-06442-8.
Evidence shows that majority of dermatological disorders affect the health-related quality of life (HRQoL) of patients. However, the extent of its negative impact and predictors has not been studied in Ethiopia. Thus, this study looked at assessing the HRQoL and determinants in patients with dermatological disorders (DDs) attending the University of Gondar Comprehensive Specialized Hospital (UoGCSH).
Patients with dermatological disorders (n = 400) were included in the final analysis using a systematic random sampling technique. The mean age of the participants was 39.79 (± 17.17) years. The average (± SD) score of EQ-5D-5 L was 1.92 (± 0.74). Regarding domains, pain/discomfort accounted for a higher proportion 59 (22.3%) followed by anxiety/depression 61 (15.3%). Receiving topical preparations (β = -0.399, 95% CI: -0.6, - 0.19; < 0.001), systemic only medication (β = -0.378, 95% CI: -0.607, -0.149; p = 0.002), having slight, mild, and moderate skin diseases found to have an inverse association with impaired HRQoL, (β = -0.654, 95% CI; -1.01, -0.290); p < 0.001), (β = -0.748, 95% CI: -0.960, -0.538; p < 0.001), and (β = -0.465, 95% CI: -0.642, -0.283; p < 0.001), respectively. Furthermore, age (β = 0.011, 95% CI: 0.006, 0.016; p = 0.001), long duration with skin disease (β = 0.046, 95% CI: 0.015, 0.352; p = 0.013), and presence of comorbidity (β = 0.251, 95% CI: 0.096, 0.402; p = 0.002) were significant predictors of HRQoL among dermatological disease patients.
Patients with dermatological disease were found to have a compromised HRQoL. Pain /discomfort problems accounted for a higher proportion compared with other domains. Socio-demographic, clinical and medication-related variables were significantly associated with HRQoL.
有证据表明，大多数皮肤病会影响患者的健康相关生活质量（HRQoL）。然而，在埃塞俄比亚，其负面影响的程度及其预测因素尚未得到研究。因此，本研究旨在评估在古德勒兹大学综合专科医院（UoGCSH）就诊的皮肤病患者的 HRQoL 和决定因素。
采用系统随机抽样技术，最终纳入 400 名皮肤病患者进行分析。参与者的平均年龄为 39.79（±17.17）岁。EQ-5D-5L 的平均（±SD）评分是 1.92（±0.74）。关于各领域，疼痛/不适占比更高，59 例（22.3%），其次是焦虑/抑郁 61 例（15.3%）。接受局部制剂（β=-0.399，95%CI：-0.6，-0.19；<0.001）、全身用药（β=-0.378，95%CI：-0.607，-0.149；p=0.002）、患有轻微、轻度和中度皮肤病与 HRQoL 受损呈负相关（β=-0.654，95%CI；-1.01，-0.290）；p<0.001），（β=-0.748，95%CI：-0.960，-0.538；p<0.001）和（β=-0.465，95%CI：-0.642，-0.283；p<0.001）。此外，年龄（β=0.011，95%CI：0.006，0.016；p=0.001）、皮肤病病程长（β=0.046，95%CI：0.015，0.352；p=0.013）和合并症（β=0.251，95%CI：0.096，0.402；p=0.002）是皮肤病患者 HRQoL 的显著预测因素。
患有皮肤病的患者被发现 HRQoL 受损。与其他领域相比，疼痛/不适问题占比更高。社会人口统计学、临床和药物相关变量与 HRQoL 显著相关。
