Centre for Dementia Prevention, University of Edinburgh.
Inserm, U1061 Neuropsychiatry, University of Montpellier.
Psychol Aging. 2021 Mar;36(2):288-297. doi: 10.1037/pag0000597. Epub 2021 Mar 4.
The hippocampus, through its mediation of fear responses is thought to play a central role in the onset and maintenance of anxiety disorders. Prevalence of anxiety disorders remains high in older populations; however, little is known about their association with hippocampal changes in this age group. Due to differing levels of cortisol as adults age, age-related decreases in hippocampal volume, and the suggestion that age-related loss of neurogenesis results in anxiety disorders, this area requires investigation. We examined the association between hippocampal volume and anxiety disorders (social anxiety disorder, generalized anxiety disorder, agoraphobia, panic disorder, obsessive compulsive disorder and posttraumatic stress disorder) in 534 older adults participating in the Enquête de Santé Psychologique-Risques, Incidence et Traitement (ESPRIT) study of late-life neuropsychiatric disorders. Anxiety disorders were diagnosed using the Mini International Neuropsychiatric Interview MINI, French version 5.00. Cross-sectional analyses adjusted for age, educational level, gender, Mini-Mental State Examination scores, National Adult Reading Test scores, whole brain volume and depression found that a diagnosis of generalized anxiety disorder was positively associated with larger hippocampal volume. No other anxiety disorder was significantly associated with hippocampal volume. The present study is the first to examine the association between several anxiety disorders and hippocampal volume in an older population and the results highlight the need for further research relating to the relationship between hippocampal volume and anxiety disorders in older adults. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
海马体通过介导恐惧反应，被认为在焦虑障碍的发生和维持中起着核心作用。焦虑障碍在老年人群中的患病率仍然很高；然而，人们对其与该年龄组海马体变化的关系知之甚少。由于成年人的皮质醇水平不同、随着年龄的增长海马体体积减少，以及年龄相关的神经发生丧失导致焦虑障碍的说法，这一领域需要进一步研究。我们在参加晚年神经精神障碍的 Enquête de Santé Psychologique-Risques，Incidence et Traitement（ESPRIT）研究的 534 名老年人中，检查了海马体体积与焦虑障碍（社交焦虑障碍、广泛性焦虑障碍、广场恐怖症、惊恐障碍、强迫症和创伤后应激障碍）之间的关联。使用 Mini International Neuropsychiatric Interview MINI，法语 5.00 版本诊断焦虑障碍。横断面分析调整了年龄、教育水平、性别、Mini-Mental State Examination 评分、全国成人阅读测试评分、全脑体积和抑郁因素，发现广泛性焦虑障碍的诊断与更大的海马体体积呈正相关。没有其他焦虑障碍与海马体体积显著相关。本研究首次在老年人群中检查了几种焦虑障碍与海马体体积之间的关系，结果强调了需要进一步研究与老年人海马体体积和焦虑障碍之间的关系。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
