Wozniak Kaitlin T, Manning Zachary A, Huang Ruiting, Cox Steven, Butler Sam C, Ferlo Sebastian, Zheleznyak Len, Xu Lisen, Ellis Jonathan D, Huxlin Krystel R, Knox Wayne H
The Flaum Eye Institute, University of Rochester, Rochester, NY 14642, USA.
The Center for Visual Science, University of Rochester, Rochester, NY 14627, USA.
Biomed Opt Express. 2024 Oct 8;15(11):6242-6258. doi: 10.1364/BOE.537705. eCollection 2024 Nov 1.
To find optimal conditions for performing laser induced refractive index change (LIRIC) in living eyes with both safety and efficacy, we investigated multiphoton excitation scaling of this procedure in hydrogel and excised corneal tissue. Three distinct wavelength modalities were examined: high-repetition-rate (HRR) and low-repetition-rate (LRR) 405 nm systems, as well as 800 nm and 1035 nm systems, whose LIRIC-inducing properties are described for the first time. Of all the systems, LRR 405 nm-LIRIC was able to produce the highest phase shifts at the lowest average laser powers. Relative merits and drawbacks to each modality are discussed as they relate to future efforts towards LIRIC-based refractive error correction in humans.
为了找到在活体眼睛中安全且有效地进行激光诱导折射率变化（LIRIC）的最佳条件，我们研究了该过程在水凝胶和离体角膜组织中的多光子激发比例。研究了三种不同的波长模式：高重复率（HRR）和低重复率（LRR）405 nm系统，以及800 nm和1035 nm系统，首次描述了它们诱导LIRIC的特性。在所有系统中，LRR 405 nm-LIRIC能够在最低平均激光功率下产生最高的相移。讨论了每种模式的相对优缺点，因为它们与未来基于LIRIC的人类屈光不正矫正的努力相关。
