Shahbaz Muhammad, Naeem Hammad, Batool Maryam, Imran Muhammad, Hussain Muzzamal, Mujtaba Ahmed, Alsagaby Suliman A, Al Abdulmonem Waleed, El-Ghorab Ahmed H, Ghoneim Mohammed M, Shaker Mohamed E, Abdelgawad Mohamed A, Al Jbawi Entessar
Department of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture Multan Multan Pakistan.
Food Technology Section, Post-Harvest Research Centre Ayub Agricultural Research Institute Faisalabad Pakistan.
Food Sci Nutr. 2024 Jul 9;12(9):6157-6173. doi: 10.1002/fsn3.4312. eCollection 2024 Sep.
a widely recognized plant more commonly known as moringa, has obtained significant research interest in recent years due to its prospective physiological advantages, including its claimed ability to counteract carcinogenesis. The moringa plant has been found to possess bioactive components that exhibit promising anticancer activities against different human cancers, such as breast cancer, prostate cancer, pancreatic cancer, etc. The cytotoxic properties of moringa seed extracts on cancerous cells have also been provided in this paper along with other notable health benefits. The extracts derived from moringa seeds inhibit cancer proliferation and promote cancer cell apoptosis through multiple signaling pathways. They also stimulated intracellular reactive oxygen species (ROS) production and subsequently induced caspase-3 activity. The impact of moringin and avenanthramide 2f on the stimulation of caspases 2, 4, 8, and 9 results in reduction in the proliferation of cancer cells. The results reported by research studies hold significant implications for identifying and targeting specific molecular entities that could serve as potential therapeutic targets in search of effective cancer treatments. Furthermore, the flavonoids in moringa seed can remove mitochondrial reactive oxygen species, protecting beta cells and bringing hyperglycemia under control. seed oil can reduce the risk of cardiovascular diseases via reduced malondialdehyde (MDA) formation and modulation of cardiac superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity. This article provides a comprehensive summary of the noteworthy discoveries derived from a rigorous investigation that explored into the impact of moringa seeds on the prevention/reduction of various cancers and other complex diseases.
一种被广泛认可的植物,更常见的名称是辣木,近年来因其潜在的生理优势而获得了重大的研究关注,包括其据称具有的对抗致癌作用的能力。人们发现辣木植物含有生物活性成分,这些成分对不同的人类癌症,如乳腺癌、前列腺癌、胰腺癌等,表现出有前景的抗癌活性。本文还介绍了辣木种子提取物对癌细胞的细胞毒性特性以及其他显著的健康益处。辣木种子提取物通过多种信号通路抑制癌症增殖并促进癌细胞凋亡。它们还刺激细胞内活性氧(ROS)的产生,随后诱导半胱天冬酶 - 3的活性。辣木素和燕麦酰胺2f对半胱天冬酶2、4、8和9的刺激作用导致癌细胞增殖减少。研究报告的结果对于识别和靶向特定的分子实体具有重要意义,这些分子实体可作为寻找有效癌症治疗方法的潜在治疗靶点。此外,辣木种子中的黄酮类化合物可以清除线粒体活性氧,保护β细胞并控制高血糖。种子油可以通过减少丙二醛(MDA)的形成以及调节心脏超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPx)的活性来降低心血管疾病的风险。本文全面总结了一项严谨调查得出的值得注意的发现,该调查探讨了辣木种子对预防/减少各种癌症和其他复杂疾病的影响。