Omodanisi Elizabeth I, Aboua Yapo G, Oguntibeju Oluwafemi O
Phytomedicine and Diabetes Research Group, Oxidative Stress Research Centre, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa.
Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa.
Molecules. 2017 Mar 23;22(4):439. doi: 10.3390/molecules22040439.
Diabetes mellitus is an endocrine disease of multiple aetiologies in insulin secretion. A deficiency in insulin results in hyperglycemia with metabolic disturbances of biomolecules. (MO) is endemic in the tropics with a variety of ethnomedicinal importance. The leaf of this plant has been reported to possess antioxidant and medicinal properties that may be helpful in the treatment and management of diabetes and its associated complications. Diabetes was induced intraperitoneally in rats by a single dose of streptozotocin (55 mg/kg) and treated with methanolic extract of (250 mg/kg b.wt) for six weeks. Forty-eight (48) adult male Wistar strain rats were randomly divided into four groups: normal control (NC), treated control rats (NC + MO), diabetic rats (DM) and treated diabetic rats (DM + MO). Estimation of antioxidant capacity, total polyphenols, flavonoids and flavonols content of extract was performed and serum biochemical markers were evaluated. Antioxidants such as catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) activities, glutathione (GSH) and inflammatory biomarkers were determined in the kidney. Results showed high antioxidant capacities of MO extract and improved serum biochemical markers, whilst lipid peroxidation (MDA) levels were reduced in non-diabetic and diabetic rats after MO treatment when compared to normal control. Subsequent administration of MO led to an increased concentration of serum albumin, globulin and total protein with a decrease in the level of MDA, and improvements in CAT, SOD, GSH, GPx, (tumour necrosis factor-alpha)TNF-α and (interleukin-6)IL-6. MO contains potent phytochemical constituents that offer protective action against diabetic-induced renal damage, reactive oxygen species (ROS) and inflammation and could therefore play a role in reducing diabetic complications, particularly in developing countries such as in Africa where the majority cannot afford orthodox medicine.
糖尿病是一种胰岛素分泌方面存在多种病因的内分泌疾病。胰岛素缺乏会导致血糖升高以及生物分子的代谢紊乱。（文中未提及的某种植物，用MO指代）在热带地区流行，具有多种民族药用价值。据报道，这种植物的叶子具有抗氧化和药用特性，可能有助于治疗和管理糖尿病及其相关并发症。通过单剂量腹腔注射链脲佐菌素（55毫克/千克）诱导大鼠患糖尿病，并用（文中未提及的某种植物，用MO指代）的甲醇提取物（250毫克/千克体重）治疗六周。48只成年雄性Wistar品系大鼠被随机分为四组：正常对照组（NC）、（文中未提及的某种植物，用MO指代）处理的对照大鼠（NC + MO）、糖尿病大鼠（DM）和（文中未提及的某种植物，用MO指代）处理的糖尿病大鼠（DM + MO）。对（文中未提及的某种植物，用MO指代）提取物的抗氧化能力、总多酚、黄酮类化合物和黄酮醇含量进行了测定，并评估了血清生化标志物。在肾脏中测定了抗氧化剂如过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、超氧化物歧化酶（SOD）活性、谷胱甘肽（GSH）以及炎症生物标志物。结果显示，（文中未提及的某种植物，用MO指代）提取物具有较高的抗氧化能力，血清生化标志物得到改善，与正常对照组相比，MO处理后的非糖尿病和糖尿病大鼠的脂质过氧化（MDA）水平降低。随后给予（文中未提及的某种植物，用MO指代）导致血清白蛋白、球蛋白和总蛋白浓度升高，MDA水平降低，CAT、SOD、GSH、GPx、（肿瘤坏死因子-α）TNF-α和（白细胞介素-6）IL-6得到改善。（文中未提及的某种植物，用MO指代）含有有效的植物化学成分，可对糖尿病诱导的肾损伤、活性氧（ROS）和炎症提供保护作用，因此在减少糖尿病并发症方面可能发挥作用，特别是在非洲等大多数人负担不起正统药物的发展中国家。
