Kozek Lindsay K, Morcos David, Hoyek Sandra, Patel Nimesh A
Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
J Vitreoretin Dis. 2024 Aug 12:24741264241271707. doi: 10.1177/24741264241271707.
To describe choriocapillaris loss on optical coherence tomography angiography (OCTA) imaging in a pediatric patient with congenital cytomegalovirus (CMV). A case was evaluated. A 7-year-old female patient was referred for retinal evaluation of maculopathy in the right eye. She was diagnosed with congenital CMV at 14 months of age, at which time treatment was not deemed necessary. At 7 years of age, the patient was asymptomatic with 20/20 Snellen visual acuity. Funduscopy and colored fundus photographs showed macular scarring. Ancillary testing was performed, with retinal pigment epithelium alterations and disruption of the outer retinal layers seen on OCT and choriocapillaris loss in the area of the macular scar seen on OCTA. For patients with congenital CMV, OCTA imaging can show significant changes in choriocapillaris function. These changes do not necessarily correlate with visual function parameters. OCTA may be useful as an additional screening or surveillance modality for patients with congenital CMV or CMV retinitis.
描述先天性巨细胞病毒（CMV）感染的儿科患者光学相干断层扫描血管造影（OCTA）成像中的脉络膜毛细血管层缺失情况。评估了1例病例。一名7岁女性患者因右眼黄斑病变接受视网膜评估。她在14个月大时被诊断为先天性CMV感染，当时认为无需治疗。7岁时，患者无症状，Snellen视力为20/20。眼底镜检查和彩色眼底照片显示黄斑瘢痕形成。进行了辅助检查，光学相干断层扫描（OCT）显示视网膜色素上皮改变和外层视网膜层破坏，OCTA显示黄斑瘢痕区域脉络膜毛细血管层缺失。对于先天性CMV感染患者，OCTA成像可显示脉络膜毛细血管层功能的显著变化。这些变化不一定与视觉功能参数相关。OCTA可能作为先天性CMV感染或CMV视网膜炎患者的额外筛查或监测手段。
