Xu Yunqiang, Qian Xiulian, Zhang Minqiao, Liang Ming
Yunqiang Xu, Department of Psychiatry, Xiangshan County Hospital of Traditional Chinese Medicine, Medical and Health Group Third Hospital, Ningbo 315700, Zhejiang, China.
Xiulian Qian Department of Psychiatry, The Third Hospital of Quzhou, Ningbo 315700, Zhejiang, China.
Pak J Med Sci. 2024 Nov;40(10):2319-2323. doi: 10.12669/pjms.40.10.8923.
To investigate the correlations of cognitive function with serum levels of homocysteine (Hcy), sex hormone binding globulin (SHBG), and leptin in patients with schizophrenia.
This was retrospective study. This study included 58 patients with schizophrenia (SCZ) as observation group and 60 clinically healthy individuals as control group admitted to Xiangshan County Hospital of Traditional Chinese Medicine Medical and Health Group Third Hospital from March 2022 to June 2023. Serum levels of Hcy, SHBG, and leptin in the two groups were measured, and Pearson correlation analysis was conducted to investigate the correlations between the Hcy, SHBG, and leptin levels and the psychiatric symptoms and cognitive function in the observation group.
The Hcy and SHBG levels in the observation group were significantly higher than those in the control group (0.05, respectively), and the leptin level was lower than that in the control group (0.05). The observation group scored significantly lower than the control group for each dimension of the MCCB (0.05, respectively). In the observation group, Hcy was positively correlated with negative symptoms and the PANSS total score (0.05, respectively) and was negatively correlated with scores for the leptin was negatively correlated with negative symptoms and the PANSS total score (0.05, respectively) and was positively correlated with scores for speed of processing (SOP), WMS-III, BVMT, and MSCEIT (0.05, respectively).
Increased levels of Hcy and SHBG and decreased leptin are strongly associated with the occurrence of cognitive impairment in SCZ cases. Therefore, clinical observation and monitoring of these markers can help identify changes in patient conditions.
探讨精神分裂症患者认知功能与血清同型半胱氨酸（Hcy）、性激素结合球蛋白（SHBG）及瘦素水平的相关性。
本研究为回顾性研究。选取2022年3月至2023年6月在象山县中医医疗健康集团第三医院收治的58例精神分裂症患者作为观察组，60例临床健康个体作为对照组。检测两组患者血清Hcy、SHBG及瘦素水平，并采用Pearson相关性分析探讨观察组Hcy、SHBG及瘦素水平与精神症状及认知功能的相关性。
观察组Hcy和SHBG水平显著高于对照组（均P<0.05），瘦素水平低于对照组（P<0.05）。观察组在蒙特利尔认知评估量表（MCCB）各维度得分均显著低于对照组（均P<0.05）。观察组中，Hcy与阴性症状及阳性和阴性症状量表（PANSS）总分呈正相关（均P<0.05），与加工速度（SOP）、韦氏记忆量表第三版（WMS-III）、本顿视觉保持测验（BVMT）及多维度情绪智力量表（MSCEIT）得分呈负相关（均P<0.05）；瘦素与阴性症状及PANSS总分呈负相关（均P<0.05），与SOP、WMS-III、BVMT及MSCEIT得分呈正相关（均P<0.05）。
Hcy和SHBG水平升高及瘦素水平降低与精神分裂症患者认知障碍的发生密切相关。因此，临床观察和监测这些指标有助于识别患者病情变化。
