Department of Psychiatry, Beijing Hui Long Guan Hospital, Peking University Hui Long Guan Clinical Medical School, Beijing, 100096, People's Republic of China.
Department of Psychiatry, The Fourth People's Hospital of Lianyungang, The Affiliated KangDa College of Nanjing Medical University, Lianyungang, 222003, People's Republic of China.
BMC Psychiatry. 2022 Dec 3;22(1):759. doi: 10.1186/s12888-022-04416-x.
Accumulating evidence shows that homocysteine (Hcy) is implicated in the pathophysiology of schizophrenia, and plays an important role in clinical characteristics. This study evaluated the relationships between Hcy levels and clinical features in first-episode, Chinese Han, drug-naïve (FEDN) patients with schizophrenia.
FEDN individuals (119 with schizophrenia and 81 healthy controls matched for age, sex, education, and body mass index (BMI)) were enrolled. The serum Hcy levels were determined by enzyme cycle assay experiments. Severities of clinical symptoms were rated on the Positive and Negative Syndrome Scale (PANSS).
FEDN individuals with schizophrenia had higher Hcy levels compared with healthy controls (F = 46.865, P < 0.001). Correlation analysis and multiple stepwise regression analyses showed that serum Hcy levels in FEDN schizophrenia individuals were positively correlated with PANSS general psychopathology subscale (r = 0.294, P = 0.001) and PANSS total score (r = 0.273, P = 0.003). No significant association was found between Hcy and age, BMI, PANSS positive subscale, and the PANSS negative subscale (all, P > 0.05). Male individuals had significantly higher serum Hcy levels than female individuals (F = 7.717, P = 0.006) after controlling for confounding factors (F = 0.759, P = 0.011).
Serum Hcy levels were increased in FEDN individuals with schizophrenia, and Hcy levels may be involved in pathophysiological mechanisms. Sex differences in Hcy levels were observed, with higher levels in male FEDN individuals compared to females.
越来越多的证据表明，同型半胱氨酸（Hcy）与精神分裂症的病理生理学有关，并在临床特征中发挥重要作用。本研究评估了首发、汉族、未经药物治疗的精神分裂症患者（FEDN）的 Hcy 水平与临床特征之间的关系。
纳入 119 例精神分裂症患者和 81 例年龄、性别、教育程度和体重指数（BMI）相匹配的健康对照者。采用酶循环试验检测血清 Hcy 水平。采用阳性和阴性症状量表（PANSS）评定临床症状严重程度。
精神分裂症 FEDN 患者的 Hcy 水平高于健康对照组（F=46.865，P<0.001）。相关分析和多元逐步回归分析显示，FEDN 精神分裂症患者的血清 Hcy 水平与 PANSS 一般精神病学分量表（r=0.294，P=0.001）和 PANSS 总分（r=0.273，P=0.003）呈正相关。Hcy 与年龄、BMI、PANSS 阳性量表和 PANSS 阴性量表之间无显著相关性（均 P>0.05）。控制混杂因素后，男性的血清 Hcy 水平显著高于女性（F=7.717，P=0.006）（F=0.759，P=0.011）。
FEDN 精神分裂症患者的血清 Hcy 水平升高，Hcy 水平可能参与病理生理机制。在 Hcy 水平方面观察到性别差异，男性 FEDN 患者的水平高于女性。
