Kalhoro Aurangzeb, Ahmed Kashif, Hashim Abdul Sattar M
Aurangzeb Kalhoro, Pakistan Gamma Knife Center, Neurospinal & Cancer Care Institute, Karachi, Pakistan.
Kashif Ahmed, Pakistan Gamma Knife Center, Neurospinal & Cancer Care Institute, Karachi, Pakistan.
Pak J Med Sci. 2024 Nov;40(10):2176-2180. doi: 10.12669/pjms.40.10.9658.
In the past, brain stem was treated with surgery or placement of shunt in Pakistan. Gamma Knife surgery is currently an alternative to surgery for deep brain lesions. In the current study, we show the clinical experience of our Centre treated with Gamma Knife surgery.
This is a descriptive study conducted between February 2016 and October 2021. We had total 47 patients presented with focal brainstem gliomas which were selected for Gamma knife radiosurgery at the Neurospinal and Cancer Care Institute Karachi.
Clinical Response was observed among them 20 (42.55%) patients improved, 22(46.80%) were stable, while 05 (10.63%) got worse The mean duration of symptoms was 31.9(SD10.5± 3months). Karnofsky Performance Status (KPS) scores during Gamma knife radiosurgery were 90 in 24 patients (51%), 80 in 21 patients (44.6%), and 70 in two patients (4.2%). Four patients (10.6%) had received conventional radiotherapy before Gamma knife radiosurgery.
Among the diverse gliomas, their peril varies not just by type but also by their intricate location within the brain. The efficacy of gamma knife radiation is excellent particularly when tackling high-grade tumors, exhibiting its prowess in both adult and pediatric cases.
过去在巴基斯坦，脑干疾病采用手术或分流术治疗。伽玛刀手术目前是治疗深部脑病变的手术替代方案。在本研究中，我们展示了本中心采用伽玛刀手术的临床经验。
这是一项于2016年2月至2021年10月期间开展的描述性研究。我们共有47例患有局灶性脑干胶质瘤的患者，这些患者在卡拉奇神经脊髓与癌症护理研究所接受了伽玛刀放射外科治疗。
观察到临床反应，其中20例（42.55%）患者病情改善，22例（46.80%）病情稳定，而5例（10.63%）病情恶化。症状的平均持续时间为31.9（标准差10.5±3个月）。伽玛刀放射外科治疗期间，卡诺夫斯基功能状态（KPS）评分：24例患者（51%）为90分，21例患者（44.6%）为80分，2例患者（4.2%）为70分。4例患者（10.6%）在伽玛刀放射外科治疗前接受过传统放疗。
在各种胶质瘤中，其风险不仅因类型而异，还因其在脑内的复杂位置而异。伽玛刀放疗的疗效极佳，尤其是在治疗高级别肿瘤时，在成人和儿童病例中均显示出其优势。
